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1gx1

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[[Image:1gx1.png|left|200px]]
 
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{{STRUCTURE_1gx1| PDB=1gx1 | SCENE= }}
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==Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase==
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<StructureSection load='1gx1' size='340' side='right'caption='[[1gx1]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1gx1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_BL21 Escherichia coli BL21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GX1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDP:CYTIDINE-5-DIPHOSPHATE'>CDP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gx1 OCA], [https://pdbe.org/1gx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gx1 RCSB], [https://www.ebi.ac.uk/pdbsum/1gx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gx1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ISPF_ECOLI ISPF_ECOLI] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). Also converts 4-diphosphocytidyl-2-C-methyl-D-erythritol into 2-C-methyl-D-erythritol 3,4-cyclophosphate and CMP.<ref>PMID:10694574</ref> <ref>PMID:22839733</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gx/1gx1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gx1 ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE===
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==See Also==
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*[[MECDP synthase|MECDP synthase]]
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{{ABSTRACT_PUBMED_11997478}}
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*[[MECDP synthase 3D structures|MECDP synthase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[1gx1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GX1 OCA].
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__TOC__
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</StructureSection>
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==Reference==
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[[Category: Escherichia coli BL21]]
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<ref group="xtra">PMID:011997478</ref><references group="xtra"/>
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[[Category: Large Structures]]
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[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
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[[Category: Bond CS]]
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[[Category: Escherichia coli]]
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[[Category: Hunter WN]]
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[[Category: Bond, C S.]]
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[[Category: Kemp LE]]
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[[Category: Hunter, W N.]]
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[[Category: Kemp, L E.]]
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[[Category: Isoprene biosynthesis]]
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[[Category: Isoprenoid]]
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[[Category: Lyase]]
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[[Category: Synthase]]
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Current revision

Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase

PDB ID 1gx1

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