1g73

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1g73" [edit=sysop:move=sysop])
Current revision (07:23, 7 February 2024) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1g73.png|left|200px]]
 
-
{{STRUCTURE_1g73| PDB=1g73 | SCENE= }}
+
==CRYSTAL STRUCTURE OF SMAC BOUND TO XIAP-BIR3 DOMAIN==
-
 
+
<StructureSection load='1g73' size='340' side='right'caption='[[1g73]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
===CRYSTAL STRUCTURE OF SMAC BOUND TO XIAP-BIR3 DOMAIN===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1g73]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G73 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_11140638}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g73 OCA], [https://pdbe.org/1g73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g73 RCSB], [https://www.ebi.ac.uk/pdbsum/1g73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g73 ProSAT]</span></td></tr>
-
[[1g73]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G73 OCA].
+
</table>
-
 
+
== Disease ==
-
==Reference==
+
[https://www.uniprot.org/uniprot/DBLOH_HUMAN DBLOH_HUMAN] Defects in DIABLO are the cause of deafness autosomal dominant type 64 (DFNA64) [MIM:[https://omim.org/entry/614152 614152]. DFNA64 is a form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:21722859</ref>
-
<ref group="xtra">PMID:011140638</ref><references group="xtra"/>
+
== Function ==
 +
[https://www.uniprot.org/uniprot/DBLOH_HUMAN DBLOH_HUMAN] Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.<ref>PMID:10929711</ref> <ref>PMID:14523016</ref> <ref>PMID:15200957</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g7/1g73_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g73 ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Chai, J.]]
+
[[Category: Large Structures]]
-
[[Category: Shi, Y.]]
+
[[Category: Chai J]]
-
[[Category: Suber, T L.]]
+
[[Category: Shi Y]]
-
[[Category: Wu, G.]]
+
[[Category: Suber TL]]
-
[[Category: Wu, J W.]]
+
[[Category: Wu G]]
-
[[Category: Apoptosis-apoptosis inhibitor complex]]
+
[[Category: Wu J-W]]
-
[[Category: Helix bundle]]
+
-
[[Category: Zinc-binding domain]]
+

Current revision

CRYSTAL STRUCTURE OF SMAC BOUND TO XIAP-BIR3 DOMAIN

PDB ID 1g73

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1g73"
Personal tools