1gxk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:09, 13 December 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1gxk.png|left|200px]]
 
-
{{STRUCTURE_1gxk| PDB=1gxk | SCENE= }}
+
==SMC hinge domain from T. maritima w/o coiled coil, P212121 crystal form==
 +
<StructureSection load='1gxk' size='340' side='right'caption='[[1gxk]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1gxk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GXK FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gxk OCA], [https://pdbe.org/1gxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gxk RCSB], [https://www.ebi.ac.uk/pdbsum/1gxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gxk ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q9X0R4_THEMA Q9X0R4_THEMA] Required for chromosome condensation and partitioning.[HAMAP-Rule:MF_01894]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gx/1gxk_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gxk ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Sister chromatids are held together by the multisubunit cohesin complex, which contains two SMC (Smc1 and Smc3) and two non-SMC (Scc1 and Scc3) proteins. The crystal structure of a bacterial SMC "hinge" region along with EM studies and biochemical experiments on yeast Smc1 and Smc3 proteins show that SMC protamers fold up individually into rod-shaped molecules. A 45 nm long intramolecular coiled coil separates the hinge region from the ATPase-containing "head" domain. Smc1 and Smc3 bind to each other via heterotypic interactions between their hinges to form a V-shaped heterodimer. The two heads of the V-shaped dimer are connected by different ends of the cleavable Scc1 subunit. Cohesin therefore forms a large proteinaceous loop within which sister chromatids might be entrapped after DNA replication.
-
===SMC HINGE DOMAIN FROM T. MARITIMA W/O COILED COIL, P212121 CRYSTAL FORM===
+
Molecular architecture of SMC proteins and the yeast cohesin complex.,Haering CH, Lowe J, Hochwagen A, Nasmyth K Mol Cell. 2002 Apr;9(4):773-88. PMID:11983169<ref>PMID:11983169</ref>
-
{{ABSTRACT_PUBMED_11983169}}
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
==About this Structure==
+
<div class="pdbe-citations 1gxk" style="background-color:#fffaf0;"></div>
-
[[1gxk]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GXK OCA].
+
== References ==
-
 
+
<references/>
-
==Reference==
+
__TOC__
-
<ref group="xtra">PMID:011983169</ref><references group="xtra"/>
+
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
-
[[Category: Haering, C.]]
+
[[Category: Haering C]]
-
[[Category: Lowe, J.]]
+
[[Category: Lowe J]]
-
[[Category: Nasmyth, K.]]
+
[[Category: Nasmyth K]]
-
[[Category: Anti parallel coiled coil]]
+
-
[[Category: Chromosome segregation]]
+
-
[[Category: Complete proteome.]]
+
-
[[Category: Smc dimerisation domain]]
+
-
[[Category: Smc protein]]
+

Current revision

SMC hinge domain from T. maritima w/o coiled coil, P212121 crystal form

PDB ID 1gxk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gxk"
Personal tools