1h9v

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[[Image:1h9v.png|left|200px]]
 
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{{STRUCTURE_1h9v| PDB=1h9v | SCENE= }}
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==Human Fc-gamma-Receptor IIa (FcgRIIa), monoclinic==
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<StructureSection load='1h9v' size='340' side='right'caption='[[1h9v]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1h9v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H9V FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h9v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h9v OCA], [https://pdbe.org/1h9v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h9v RCSB], [https://www.ebi.ac.uk/pdbsum/1h9v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h9v ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FCG2A_HUMAN FCG2A_HUMAN] Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.<ref>PMID:19011614</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h9/1h9v_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h9v ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Once antigen is opsonised by IgG it is removed from the circulation by Fcgamma-receptor expressing cells. Fcgamma-receptors are type I transmembrane molecules that carry extracellular parts consisting of two or three immunoglobulin domains. Previously solved structures of Fc-receptors reveal that the N-terminal two Ig-like domains are arranged in a steep angle forming a heart-shaped structure. The crystal structure of the FcgammaRIII/hIgG1-Fc-fragment demonstrated that the Fc-fragment is recognised through loops of the C-terminal receptor domain of the FcgammaRIII. As the overall structure of the FcRs and their Ig ligands are very similar we modelled the Ig complexes with FcgammaRI, FcgammaRII and FcepsilonRIalpha based on the FcgammaRIII/hIgG1-Fc-fragment structure. The obtained models are consistent with the observed biochemical data and may explain the observed specificity and affinities.
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===HUMAN FC-GAMMA-RECEPTOR IIA (FCGRIIA), MONOCLINIC===
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Molecular basis for immune complex recognition: a comparison of Fc-receptor structures.,Sondermann P, Kaiser J, Jacob U J Mol Biol. 2001 Jun 8;309(3):737-49. PMID:11397093<ref>PMID:11397093</ref>
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{{ABSTRACT_PUBMED_11397093}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1h9v" style="background-color:#fffaf0;"></div>
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[[1h9v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H9V OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:011397093</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Jacob, U.]]
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[[Category: Large Structures]]
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[[Category: Kaiser, J.]]
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[[Category: Jacob U]]
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[[Category: Sondermann, P.]]
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[[Category: Kaiser J]]
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[[Category: Fc-gamma-r]]
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[[Category: Sondermann P]]
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[[Category: Fc-receptor]]
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[[Category: Fcgr]]
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[[Category: Fcr]]
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[[Category: Immune system]]
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[[Category: Immunoglobulin]]
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[[Category: Membrane protein]]
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Current revision

Human Fc-gamma-Receptor IIa (FcgRIIa), monoclinic

PDB ID 1h9v

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