1i17

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[[Image:1i17.png|left|200px]]
 
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{{STRUCTURE_1i17| PDB=1i17 | SCENE= }}
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==NMR STRUCTURE OF MOUSE DOPPEL 51-157==
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<StructureSection load='1i17' size='340' side='right'caption='[[1i17]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1i17]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I17 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i17 OCA], [https://pdbe.org/1i17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i17 RCSB], [https://www.ebi.ac.uk/pdbsum/1i17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i17 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PRND_MOUSE PRND_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/1i17_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i17 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The downstream prion-like protein (doppel, or Dpl) is a paralog of the cellular prion protein, PrP(C). The two proteins have approximately 25% sequence identity, but seem to have distinct physiologic roles. Unlike PrP(C), Dpl does not support prion replication; instead, overexpression of Dpl in the brain seems to cause a completely different neurodegenerative disease. We report the solution structure of a fragment of recombinant mouse Dpl (residues 26-157) containing a globular domain with three helices and a small amount of beta-structure. Overall, the topology of Dpl is very similar to that of PrP(C). Significant differences include a marked kink in one of the helices in Dpl, and a different orientation of the two short beta-strands. Although the two proteins most likely arose through duplication of a single ancestral gene, the relationship is now so distant that only the structures retain similarity; the functions have diversified along with the sequence.
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===NMR STRUCTURE OF MOUSE DOPPEL 51-157===
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Two different neurodegenerative diseases caused by proteins with similar structures.,Mo H, Moore RC, Cohen FE, Westaway D, Prusiner SB, Wright PE, Dyson HJ Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2352-7. PMID:11226243<ref>PMID:11226243</ref>
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{{ABSTRACT_PUBMED_11226243}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1i17" style="background-color:#fffaf0;"></div>
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[[1i17]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I17 OCA].
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== References ==
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<references/>
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==See Also==
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__TOC__
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*[[Doppel|Doppel]]
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:011226243</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Cohen, F E.]]
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[[Category: Cohen FE]]
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[[Category: Dyson, H J.]]
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[[Category: Dyson HJ]]
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[[Category: Mo, H.]]
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[[Category: Mo H]]
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[[Category: Moore, R C.]]
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[[Category: Moore RC]]
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[[Category: Prusiner, S B.]]
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[[Category: Prusiner SB]]
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[[Category: Westaway, D.]]
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[[Category: Westaway D]]
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[[Category: Wright, P E.]]
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[[Category: Wright PE]]
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[[Category: Doppel]]
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[[Category: Dpl]]
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[[Category: Mouse doppel]]
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[[Category: Prion]]
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[[Category: Unknown function]]
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Current revision

NMR STRUCTURE OF MOUSE DOPPEL 51-157

PDB ID 1i17

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