1gqe

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[[Image:1gqe.png|left|200px]]
 
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{{STRUCTURE_1gqe| PDB=1gqe | SCENE= }}
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==Polypeptide Chain Release Factor 2 (RF2) from Escherichia coli==
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<StructureSection load='1gqe' size='340' side='right'caption='[[1gqe]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1gqe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GQE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gqe OCA], [https://pdbe.org/1gqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gqe RCSB], [https://www.ebi.ac.uk/pdbsum/1gqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gqe ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RF2_ECOLI RF2_ECOLI] Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.[HAMAP-Rule:MF_00094]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/1gqe_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gqe ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bacterial release factor RF2 promotes termination of protein synthesis, specifically recognizing stop codons UAA or UGA. The crystal structure of Escherichia coli RF2 has been determined to a resolution of 1.8 A. RF2 is structurally distinct from its eukaryotic counterpart eRF1. The tripeptide SPF motif, thought to confer RF2 stop codon specificity, and the universally conserved GGQ motif, proposed to be involved with the peptidyl transferase center, are exposed in loops only 23 A apart, and the structure suggests that stop signal recognition is more complex than generally believed.
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===POLYPEPTIDE CHAIN RELEASE FACTOR 2 (RF2) FROM ESCHERICHIA COLI===
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Bacterial polypeptide release factor RF2 is structurally distinct from eukaryotic eRF1.,Vestergaard B, Van LB, Andersen GR, Nyborg J, Buckingham RH, Kjeldgaard M Mol Cell. 2001 Dec;8(6):1375-82. PMID:11779511<ref>PMID:11779511</ref>
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{{ABSTRACT_PUBMED_11779511}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1gqe" style="background-color:#fffaf0;"></div>
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[[1gqe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GQE OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:011779511</ref><ref group="xtra">PMID:012511960</ref><ref group="xtra">PMID:012511961</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Kjeldgaard, M.]]
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[[Category: Large Structures]]
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[[Category: Vestergaard, B.]]
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[[Category: Kjeldgaard M]]
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[[Category: Macromolecular mimicry]]
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[[Category: Vestergaard B]]
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[[Category: Protein synthesis]]
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[[Category: Ribosome]]
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[[Category: Translation]]
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Current revision

Polypeptide Chain Release Factor 2 (RF2) from Escherichia coli

PDB ID 1gqe

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