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1hyl

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[[Image:1hyl.png|left|200px]]
 
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{{STRUCTURE_1hyl| PDB=1hyl | SCENE= }}
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==THE 1.8 A STRUCTURE OF COLLAGENASE FROM HYPODERMA LINEATUM==
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<StructureSection load='1hyl' size='340' side='right'caption='[[1hyl]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hyl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hypoderma_lineatum Hypoderma lineatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HYL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hyl OCA], [https://pdbe.org/1hyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hyl RCSB], [https://www.ebi.ac.uk/pdbsum/1hyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hyl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/COGS_HYPLI COGS_HYPLI] This enzyme is a serine protease capable of degrading the native triple helix of collagen. Also cleaves the B chain of insulin at the 15-Leu-|-Try-16 and 22-Arg-|-Gly-23 bonds. Hydrolyzes casein, but not Px-Pro-Leu-Gly-Pro-DArg, BzArgNHPh, AcTyrNHPh, 2-naphthyl phosphate, 2-naphthyl butyrate, 2-naphthyl caprylate, 2-naphthyl myristate, L-leucine 2-2-naphthylamide, L-valine 2-naphthylamide, L-cysteine 2-naphthylamide or L-glutarylphenylalanine 2-naphthylamide.<ref>PMID:230030</ref> <ref>PMID:2995028</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/1hyl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hyl ConSurf].
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<div style="clear:both"></div>
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===THE 1.8 A STRUCTURE OF COLLAGENASE FROM HYPODERMA LINEATUM===
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==See Also==
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*[[Collagenase 3D structures|Collagenase 3D structures]]
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{{ABSTRACT_PUBMED_15299709}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1hyl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hypoderma_lineatum Hypoderma lineatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYL OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:015299709</ref><references group="xtra"/>
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[[Category: Hypoderma lineatum]]
[[Category: Hypoderma lineatum]]
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[[Category: Arnoux, B.]]
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[[Category: Large Structures]]
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[[Category: Broutin, I.]]
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[[Category: Arnoux B]]
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[[Category: Ducruix, A.]]
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[[Category: Broutin I]]
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[[Category: Keil, B.]]
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[[Category: Ducruix A]]
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[[Category: Lecroisey, A.]]
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[[Category: Keil B]]
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[[Category: Pascard, C.]]
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[[Category: Lecroisey A]]
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[[Category: Riche, C.]]
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[[Category: Pascard C]]
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[[Category: Riche C]]

Current revision

THE 1.8 A STRUCTURE OF COLLAGENASE FROM HYPODERMA LINEATUM

PDB ID 1hyl

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