1hlv

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[[Image:1hlv.png|left|200px]]
 
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{{STRUCTURE_1hlv| PDB=1hlv | SCENE= }}
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==CRYSTAL STRUCTURE OF CENP-B(1-129) COMPLEXED WITH THE CENP-B BOX DNA==
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<StructureSection load='1hlv' size='340' side='right'caption='[[1hlv]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hlv]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HLV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hlv OCA], [https://pdbe.org/1hlv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hlv RCSB], [https://www.ebi.ac.uk/pdbsum/1hlv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hlv ProSAT], [https://www.topsan.org/Proteins/RSGI/1hlv TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CENPB_HUMAN CENPB_HUMAN] Interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/1hlv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hlv ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF CENP-B(1-129) COMPLEXED WITH THE CENP-B BOX DNA===
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==See Also==
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*[[Centromere protein 3D structure|Centromere protein 3D structure]]
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{{ABSTRACT_PUBMED_11726497}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[1hlv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLV OCA].
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==Reference==
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<ref group="xtra">PMID:011726497</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fukai, S.]]
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[[Category: Large Structures]]
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[[Category: Ikuta, M.]]
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[[Category: Fukai S]]
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[[Category: Iwahara, J.]]
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[[Category: Ikuta M]]
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[[Category: Kawaguchi, S.]]
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[[Category: Iwahara J]]
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[[Category: Kurumizaka, H.]]
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[[Category: Kawaguchi S]]
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[[Category: Nureki, O.]]
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[[Category: Kurumizaka H]]
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[[Category: Okazaki, T.]]
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[[Category: Nureki O]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Okazaki T]]
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[[Category: Tanaka, Y.]]
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[[Category: Tanaka Y]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama S]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Helix-turn-helix]]
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[[Category: Protein-dna complex]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: Rsgi]]
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[[Category: Structural genomic]]
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Current revision

CRYSTAL STRUCTURE OF CENP-B(1-129) COMPLEXED WITH THE CENP-B BOX DNA

PDB ID 1hlv

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