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1hkw
From Proteopedia
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| - | [[Image:1hkw.png|left|200px]] | ||
| - | + | ==MYCOBACTERIUM DIAMINOPIMELATE DICARBOXYLASE (LysA)== | |
| - | + | <StructureSection load='1hkw' size='340' side='right'caption='[[1hkw]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1hkw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HKW FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hkw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkw OCA], [https://pdbe.org/1hkw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hkw RCSB], [https://www.ebi.ac.uk/pdbsum/1hkw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hkw ProSAT]</span></td></tr> |
| - | [[1hkw]] is a 2 chain structure with sequence from [ | + | </table> |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/DCDA_MYCTU DCDA_MYCTU] Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine (Probable). Is essential for the viability of M.tuberculosis in the host.<ref>PMID:12637582</ref> | |
| - | < | + | == Evolutionary Conservation == |
| - | [[ | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | [[ | + | Check<jmol> |
| - | [ | + | <jmolCheckbox> |
| - | [ | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hk/1hkw_consurf.spt"</scriptWhenChecked> |
| - | [ | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [ | + | </jmolCheckbox> |
| - | [ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hkw ConSurf]. |
| - | [[ | + | <div style="clear:both"></div> |
| - | [ | + | == References == |
| - | [[ | + | <references/> |
| - | [ | + | __TOC__ |
| - | + | </StructureSection> | |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Mycobacterium tuberculosis]] | + | [[Category: Mycobacterium tuberculosis H37Rv]] |
| - | [[Category: | + | [[Category: Gokulan K]] |
| - | [[Category: | + | [[Category: Jacobs Jr WR]] |
| - | [[Category: | + | [[Category: Pavelka Jr MS]] |
| - | [[Category: | + | [[Category: Rupp B]] |
| - | [[Category: | + | [[Category: Sacchettini JC]] |
| - | + | ||
Current revision
MYCOBACTERIUM DIAMINOPIMELATE DICARBOXYLASE (LysA)
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