1h6q

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[[Image:1h6q.png|left|200px]]
 
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{{STRUCTURE_1h6q| PDB=1h6q | SCENE= }}
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==Translationally Controlled Tumor-associated Protein p23fyp from Schizosaccharomyces pombe==
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<StructureSection load='1h6q' size='340' side='right'caption='[[1h6q]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1h6q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H6Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h6q OCA], [https://pdbe.org/1h6q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h6q RCSB], [https://www.ebi.ac.uk/pdbsum/1h6q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h6q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TCTP_SCHPO TCTP_SCHPO] Involved in calcium binding and microtubule stabilization (By similarity). May be a guanine nucleotide-free chaperone (GFC).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h6/1h6q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h6q ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The translationally controlled tumor-associated proteins (TCTPs) are a highly conserved and abundantly expressed family of eukaryotic proteins that are implicated in both cell growth and the human acute allergic response but whose intracellular biochemical function has remained elusive. We report here the solution structure of the TCTP from Schizosaccharomyces pombe, which, on the basis of sequence homology, defines the fold of the entire family. We show that TCTPs form a structural superfamily with the Mss4/Dss4 family of proteins, which bind to the GDP/GTP free form of Rab proteins (members of the Ras superfamily) and have been termed guanine nucleotide-free chaperones (GFCs). Mss4 also acts as a relatively inefficient guanine nucleotide exchange factor (GEF). We further show that the Rab protein binding site on Mss4 coincides with the region of highest sequence conservation in the TCTP family. This is the first link to any other family of proteins that has been established for the TCTP family and suggests the presence of a GFC/GEF at extremely high abundance in eukaryotic cells.
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===TRANSLATIONALLY CONTROLLED TUMOR-ASSOCIATED PROTEIN P23FYP FROM SCHIZOSACCHAROMYCES POMBE===
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Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones.,Thaw P, Baxter NJ, Hounslow AM, Price C, Waltho JP, Craven CJ Nat Struct Biol. 2001 Aug;8(8):701-4. PMID:11473261<ref>PMID:11473261</ref>
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{{ABSTRACT_PUBMED_11473261}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1h6q" style="background-color:#fffaf0;"></div>
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[[1h6q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H6Q OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:011473261</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Schizosaccharomyces pombe]]
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[[Category: Baxter, N J.]]
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[[Category: Baxter NJ]]
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[[Category: Craven, C J.]]
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[[Category: Craven CJ]]
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[[Category: Price, C.]]
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[[Category: Price C]]
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[[Category: Sedelnikova, S E.]]
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[[Category: Sedelnikova SE]]
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[[Category: Thaw, P.]]
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[[Category: Thaw P]]
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[[Category: Waltho, J P.]]
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[[Category: Waltho JP]]
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[[Category: Function unknown]]
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[[Category: Tumor-associated protein]]
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Current revision

Translationally Controlled Tumor-associated Protein p23fyp from Schizosaccharomyces pombe

PDB ID 1h6q

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