1hlo
From Proteopedia
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| - | [[Image:1hlo.png|left|200px]] | ||
| - | + | ==THE CRYSTAL STRUCTURE OF AN INTACT HUMAN MAX-DNA COMPLEX: NEW INSIGHTS INTO MECHANISMS OF TRANSCRIPTIONAL CONTROL== | |
| - | + | <StructureSection load='1hlo' size='340' side='right'caption='[[1hlo]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1hlo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HLO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hlo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hlo OCA], [https://pdbe.org/1hlo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hlo RCSB], [https://www.ebi.ac.uk/pdbsum/1hlo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hlo ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1hlo]] is a 4 chain structure with sequence from [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/MAX_HUMAN MAX_HUMAN] Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MAD-MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. | |
| - | == | + | == Evolutionary Conservation == |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/1hlo_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hlo ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Brownlie | + | [[Category: Large Structures]] |
| - | [[Category: Ceska | + | [[Category: Brownlie P]] |
| - | [[Category: Lamers | + | [[Category: Ceska TA]] |
| - | [[Category: Romier | + | [[Category: Lamers M]] |
| - | [[Category: Suck | + | [[Category: Romier C]] |
| - | [[Category: Theo | + | [[Category: Suck D]] |
| - | + | [[Category: Theo H]] | |
| - | + | ||
| - | + | ||
Current revision
THE CRYSTAL STRUCTURE OF AN INTACT HUMAN MAX-DNA COMPLEX: NEW INSIGHTS INTO MECHANISMS OF TRANSCRIPTIONAL CONTROL
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Categories: Homo sapiens | Large Structures | Brownlie P | Ceska TA | Lamers M | Romier C | Suck D | Theo H
