1gyf

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[[Image:1gyf.png|left|200px]]
 
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{{STRUCTURE_1gyf| PDB=1gyf | SCENE= }}
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==GYF DOMAIN FROM HUMAN CD2BP2 PROTEIN==
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<StructureSection load='1gyf' size='340' side='right'caption='[[1gyf]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1gyf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GYF FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gyf OCA], [https://pdbe.org/1gyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gyf RCSB], [https://www.ebi.ac.uk/pdbsum/1gyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gyf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CD2B2_HUMAN CD2B2_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gy/1gyf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gyf ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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T cell activation through the CD2 cell surface receptor is transmitted by proline-rich sequences within its cytoplasmic tail. A membrane-proximal proline-rich tandem repeat, involved in cytokine production, is recognized by the intracellular CD2 binding protein CD2BP2. We solved the solution structure of the CD2 binding domain of CD2BP2, which we name the glycine-tyrosine-phenylalanine (GYF) domain. The GYF sequence is part of a structurally unique bulge-helix-bulge motif that constitutes the major binding site for the CD2 tail. A hydrophobic surface patch is created by motif residues that are highly conserved among a variety of proteins from diverse eukaryotic species. Thus, the architecture of the GYF domain may be widely used in protein-protein associations.
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===GYF DOMAIN FROM HUMAN CD2BP2 PROTEIN===
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The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences.,Freund C, Dotsch V, Nishizawa K, Reinherz EL, Wagner G Nat Struct Biol. 1999 Jul;6(7):656-60. PMID:10404223<ref>PMID:10404223</ref>
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{{ABSTRACT_PUBMED_10404223}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1gyf" style="background-color:#fffaf0;"></div>
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[[1gyf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GYF OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:010404223</ref><ref group="xtra">PMID:011742118</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Doetsch, V.]]
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[[Category: Large Structures]]
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[[Category: Freund, C.]]
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[[Category: Doetsch V]]
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[[Category: Nishizawa, K.]]
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[[Category: Freund C]]
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[[Category: Reinherz, E L.]]
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[[Category: Nishizawa K]]
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[[Category: Wagner, G.]]
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[[Category: Reinherz EL]]
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[[Category: Adapter domain]]
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[[Category: Wagner G]]
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[[Category: Immune system]]
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[[Category: Proline-rich sequence recognition]]
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[[Category: T cell signaling]]
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Current revision

GYF DOMAIN FROM HUMAN CD2BP2 PROTEIN

PDB ID 1gyf

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