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1gxu

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[[Image:1gxu.png|left|200px]]
 
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{{STRUCTURE_1gxu| PDB=1gxu | SCENE= }}
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==Hydrogenase Maturation Protein HypF "acylphosphatase-like" N-terminal domain (HypF-ACP) in complex with a substrate. Crystal grown in the presence of carbamoylphosphate==
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<StructureSection load='1gxu' size='340' side='right'caption='[[1gxu]], [[Resolution|resolution]] 1.27&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1gxu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GXU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.27&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2HP:DIHYDROGENPHOSPHATE+ION'>2HP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gxu OCA], [https://pdbe.org/1gxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gxu RCSB], [https://www.ebi.ac.uk/pdbsum/1gxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gxu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HYPF_ECOLI HYPF_ECOLI] Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.<ref>PMID:8661925</ref> <ref>PMID:12377778</ref> <ref>PMID:15291820</ref> <ref>PMID:15504408</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gx/1gxu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gxu ConSurf].
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<div style="clear:both"></div>
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===HYDROGENASE MATURATION PROTEIN HYPF "ACYLPHOSPHATASE-LIKE" N-TERMINAL DOMAIN (HYPF-ACP) IN COMPLEX WITH A SUBSTRATE. CRYSTAL GROWN IN THE PRESENCE OF CARBAMOYLPHOSPHATE===
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==See Also==
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*[[HypA%2C HypB%2C HypC%2C HypD%2C HypE and HypF 3D structures|HypA%2C HypB%2C HypC%2C HypD%2C HypE and HypF 3D structures]]
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{{ABSTRACT_PUBMED_12206761}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1gxu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GXU OCA].
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</StructureSection>
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[[Category: Escherichia coli]]
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==Reference==
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[[Category: Large Structures]]
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<ref group="xtra">PMID:012206761</ref><references group="xtra"/>
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[[Category: Bolognesi M]]
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[[Category: Bolognesi, M.]]
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[[Category: Bucciantini M]]
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[[Category: Bucciantini, M.]]
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[[Category: Ramponi G]]
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[[Category: Ramponi, G.]]
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[[Category: Rosano C]]
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[[Category: Rosano, C.]]
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[[Category: Stefani M]]
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[[Category: Stefani, M.]]
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[[Category: Zuccotti S]]
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[[Category: Zuccotti, S.]]
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[[Category: Acylphosphatase]]
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[[Category: Fibril formation]]
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[[Category: Hydrogenase maturation]]
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[[Category: Phosphatase]]
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[[Category: Zinc-finger]]
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Current revision

Hydrogenase Maturation Protein HypF "acylphosphatase-like" N-terminal domain (HypF-ACP) in complex with a substrate. Crystal grown in the presence of carbamoylphosphate

PDB ID 1gxu

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