1qxb

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[[Image:1qxb.gif|left|200px]]<br /><applet load="1qxb" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1qxb" />
 
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'''NMR structure determination of the self complementary DNA Dodecamer CGCGAATT*CGCG in which a ribose is inserted between the 3'-OH of T8 and the 5'-phosphate group of C9'''<br />
 
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==Overview==
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==NMR structure determination of the self complementary DNA Dodecamer CGCGAATT*CGCG in which a ribose is inserted between the 3'-OH of T8 and the 5'-phosphate group of C9==
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A ribose residue inserted between the 3'-OH of one nucleotide and the 5'-phosphate group of the next nucleotide, functions as a site-specific cleavage site within DNA. This extra ribose does not interrupt helix formation and it protects duplex DNA against cleavage by restriction enzymes. Cleavage can be obtained with periodate and all ribose fragments can be removed with sodium hydroxide. As a result of this, an intact natural oligodeoxynucleotide is obtained after ligation reaction, which means that site-specific cleavage and recovering of intact DNA occurs without loss of genetic information.
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<StructureSection load='1qxb' size='340' side='right'caption='[[1qxb]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1qxb]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QXB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QXB FirstGlance]. <br>
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1QXB is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=RIB:'>RIB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QXB OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BDR:BETA-D-RIBOFURANOSYL'>BDR</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qxb OCA], [https://pdbe.org/1qxb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qxb RCSB], [https://www.ebi.ac.uk/pdbsum/1qxb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qxb ProSAT]</span></td></tr>
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Cleavage of DNA without loss of genetic information by incorporation of a disaccharide nucleoside., Nauwelaerts K, Vastmans K, Froeyen M, Kempeneers V, Rozenski J, Rosemeyer H, Van Aerschot A, Busson R, Lacey JC, Efimtseva E, Mikhailov S, Lescrinier E, Herdewijn P, Nucleic Acids Res. 2003 Dec 1;31(23):6758-69. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14627809 14627809]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Aerschot, A Van.]]
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</StructureSection>
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[[Category: Busson, R.]]
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[[Category: Large Structures]]
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[[Category: Efimtseva, E.]]
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[[Category: Busson R]]
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[[Category: Froeyen, M.]]
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[[Category: Efimtseva E]]
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[[Category: Herdewijn, P.]]
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[[Category: Froeyen M]]
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[[Category: Kempeneers, V.]]
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[[Category: Herdewijn P]]
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[[Category: Lescrinier, E.]]
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[[Category: Kempeneers V]]
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[[Category: Mikhailov, S.]]
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[[Category: Lescrinier E]]
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[[Category: Nauwelaerts, K.]]
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[[Category: Mikhailov S]]
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[[Category: Rosemeyer, H.]]
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[[Category: Nauwelaerts K]]
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[[Category: Rozenski, J.]]
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[[Category: Rosemeyer H]]
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[[Category: Vastmans, K.]]
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[[Category: Rozenski J]]
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[[Category: RIB]]
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[[Category: Van Aerschot A]]
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[[Category: b-helix]]
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[[Category: Vastmans K]]
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[[Category: backbone modification]]
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[[Category: disaccharide nucleotide]]
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[[Category: ribose]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:44:42 2008''
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Current revision

NMR structure determination of the self complementary DNA Dodecamer CGCGAATT*CGCG in which a ribose is inserted between the 3'-OH of T8 and the 5'-phosphate group of C9

PDB ID 1qxb

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