1iu1

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[[Image:1iu1.png|left|200px]]
 
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{{STRUCTURE_1iu1| PDB=1iu1 | SCENE= }}
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==Crystal structure of human gamma1-adaptin ear domain==
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<StructureSection load='1iu1' size='340' side='right'caption='[[1iu1]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1iu1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IU1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iu1 OCA], [https://pdbe.org/1iu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iu1 RCSB], [https://www.ebi.ac.uk/pdbsum/1iu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iu1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AP1G1_HUMAN AP1G1_HUMAN] Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iu/1iu1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iu1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The adaptor proteins AP-1 and GGA regulate membrane traffic between the trans-Golgi network (TGN) and endosomes/lysosomes through ARF-regulated membrane association, recognition of sorting signals, and recruitment of clathrin and accessory proteins. The gamma 1-adaptin subunits of AP-1 and GGA possess homologous ear domains involved in the recruitment of accessory proteins, gamma-synergin and Rabaptin-5. The crystal structure of the human gamma 1-adaptin ear domain consists solely of an immunoglobulin-like fold, unlike the alpha-adaptin ear domain. Structure-based mutational analyses reveal a binding site for the accessory proteins that is composed of conserved basic residues, indicating that the recruitment mechanism in gamma 1-adaptin and GGA is distinct from that in alpha-adaptin.
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===Crystal structure of human gamma1-adaptin ear domain===
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Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain.,Nogi T, Shiba Y, Kawasaki M, Shiba T, Matsugaki N, Igarashi N, Suzuki M, Kato R, Takatsu H, Nakayama K, Wakatsuki S Nat Struct Biol. 2002 Jul;9(7):527-31. PMID:12042876<ref>PMID:12042876</ref>
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{{ABSTRACT_PUBMED_12042876}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1iu1" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[1iu1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IU1 OCA].
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*[[Adaptin 3D structures|Adaptin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012042876</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Igarashi, N.]]
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[[Category: Large Structures]]
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[[Category: Kato, R.]]
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[[Category: Igarashi N]]
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[[Category: Kawasaki, M.]]
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[[Category: Kato R]]
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[[Category: Matsugaki, N.]]
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[[Category: Kawasaki M]]
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[[Category: Nakayama, K.]]
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[[Category: Matsugaki N]]
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[[Category: Nogi, T.]]
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[[Category: Nakayama K]]
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[[Category: Shiba, T.]]
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[[Category: Nogi T]]
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[[Category: Shiba, Y.]]
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[[Category: Shiba T]]
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[[Category: Suzuki, M.]]
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[[Category: Shiba Y]]
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[[Category: Takatsu, H.]]
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[[Category: Suzuki M]]
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[[Category: Wakatsuki, S.]]
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[[Category: Takatsu H]]
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[[Category: Coated pit]]
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[[Category: Wakatsuki S]]
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[[Category: Endocytosis]]
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Current revision

Crystal structure of human gamma1-adaptin ear domain

PDB ID 1iu1

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