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1r55

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[[Image:1r55.jpg|left|200px]]<br /><applet load="1r55" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1r55, resolution 1.58&Aring;" />
 
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'''Crystal structure of the catalytic domain of human ADAM 33'''<br />
 
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==Overview==
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==Crystal structure of the catalytic domain of human ADAM 33==
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Adam33 is a putative asthma susceptibility gene encoding for a membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs (a disintegrin and metalloprotease) are a family of glycoproteins implicated in cell-cell interactions, cell fusion, and cell signaling. We have determined the crystal structure of the Adam33 catalytic domain in complex with the inhibitor marimastat and the inhibitor-free form. The structures reveal the polypeptide fold and active site environment resembling that of other metalloproteases. The substrate-binding site contains unique features that allow the structure-based design of specific inhibitors of this enzyme.
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<StructureSection load='1r55' size='340' side='right'caption='[[1r55]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1r55]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R55 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=097:(2S,3R)-N~4~-[(1S)-2,2-DIMETHYL-1-(METHYLCARBAMOYL)PROPYL]-N~1~,2-DIHYDROXY-3-(2-METHYLPROPYL)BUTANEDIAMIDE'>097</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r55 OCA], [https://pdbe.org/1r55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r55 RCSB], [https://www.ebi.ac.uk/pdbsum/1r55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r55 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ADA33_HUMAN ADA33_HUMAN] Genetic variations in ADAM33 are associated with susceptibility to asthma (ASTHMA) [MIM:[https://omim.org/entry/600807 600807]. The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.<ref>PMID:12110844</ref> <ref>PMID:16773130</ref> <ref>PMID:19237393</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ADA33_HUMAN ADA33_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/1r55_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r55 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1R55 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=097:'>097</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R55 OCA].
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*[[A Disintegrin And Metalloproteinase 3D structures|A Disintegrin And Metalloproteinase 3D structures]]
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== References ==
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==Reference==
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<references/>
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Crystal structure of the catalytic domain of human ADAM33., Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V, J Mol Biol. 2004 Jan 2;335(1):129-37. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14659745 14659745]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hammond, G.]]
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[[Category: Hammond G]]
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[[Category: Le, H V.]]
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[[Category: Le HV]]
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[[Category: Madison, V.]]
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[[Category: Madison V]]
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[[Category: Mirza, U A.]]
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[[Category: Mirza UA]]
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[[Category: Orth, P.]]
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[[Category: Orth P]]
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[[Category: Prosise, W W.]]
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[[Category: Prosise WW]]
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[[Category: Reichert, P.]]
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[[Category: Reichert P]]
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[[Category: Strickland, C.]]
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[[Category: Strickland C]]
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[[Category: Taremi, S S.]]
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[[Category: Taremi SS]]
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[[Category: Wang, W.]]
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[[Category: Wang W]]
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[[Category: Xiao, L.]]
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[[Category: Xiao L]]
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[[Category: Yarosh-Tomaine, T.]]
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[[Category: Yarosh-Tomaine T]]
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[[Category: Zou, J.]]
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[[Category: Zou J]]
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[[Category: 097]]
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[[Category: CA]]
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[[Category: CL]]
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[[Category: ZN]]
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[[Category: adam]]
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[[Category: asthma]]
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[[Category: inhibitor]]
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[[Category: metalloprotease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:47:10 2008''
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Current revision

Crystal structure of the catalytic domain of human ADAM 33

PDB ID 1r55

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