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1iaj

From Proteopedia

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[[Image:1iaj.png|left|200px]]
 
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{{STRUCTURE_1iaj| PDB=1iaj | SCENE= }}
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==CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (APO)==
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<StructureSection load='1iaj' size='340' side='right'caption='[[1iaj]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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===CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (APO)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1iaj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IAJ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11389851}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1iaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iaj OCA], [https://pdbe.org/1iaj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1iaj RCSB], [https://www.ebi.ac.uk/pdbsum/1iaj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1iaj ProSAT]</span></td></tr>
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[[1iaj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IAJ OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/TRPM7_MOUSE TRPM7_MOUSE] Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).<ref>PMID:11385574</ref>
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<ref group="xtra">PMID:011389851</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/1iaj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1iaj ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Kuriyan J]]
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[[Category: Kuriyan, J.]]
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[[Category: Matsushita M]]
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[[Category: Matsushita, M.]]
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[[Category: Nairn AC]]
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[[Category: Nairn, A C.]]
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[[Category: Yamaguchi H]]
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[[Category: Yamaguchi, H.]]
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[[Category: Alpha/beta]]
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[[Category: Atp-grasp fold]]
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[[Category: Protein kinase like fold]]
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[[Category: Transferase]]
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Current revision

CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (APO)

PDB ID 1iaj

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