1j7d

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[[Image:1j7d.png|left|200px]]
 
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{{STRUCTURE_1j7d| PDB=1j7d | SCENE= }}
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==Crystal Structure of hMms2-hUbc13==
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<StructureSection load='1j7d' size='340' side='right'caption='[[1j7d]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1j7d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J7D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j7d OCA], [https://pdbe.org/1j7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j7d RCSB], [https://www.ebi.ac.uk/pdbsum/1j7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j7d ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UB2V2_HUMAN UB2V2_HUMAN] Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.<ref>PMID:9705497</ref> <ref>PMID:10089880</ref> <ref>PMID:14562038</ref> <ref>PMID:20061386</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j7/1j7d_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j7d ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of hMms2-hUbc13===
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==See Also==
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*[[3D structures of ubiquitin conjugating enzyme|3D structures of ubiquitin conjugating enzyme]]
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{{ABSTRACT_PUBMED_11473255}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1j7d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J7D OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:011473255</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ubiquitin--protein ligase]]
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[[Category: Large Structures]]
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[[Category: Edwards, R A.]]
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[[Category: Edwards RA]]
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[[Category: Ellison, M J.]]
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[[Category: Ellison MJ]]
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[[Category: Glover, J N.M.]]
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[[Category: Glover JNM]]
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[[Category: McKenna, S.]]
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[[Category: McKenna S]]
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[[Category: Moraes, T F.]]
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[[Category: Moraes TF]]
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[[Category: Pashushok, L.]]
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[[Category: Pashushok L]]
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[[Category: Xiao, W.]]
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[[Category: Xiao W]]
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[[Category: Dna repair]]
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[[Category: Nfkb]]
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[[Category: Traf6]]
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[[Category: Ubc]]
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[[Category: Ubiquitin]]
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[[Category: Unknown function]]
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Current revision

Crystal Structure of hMms2-hUbc13

PDB ID 1j7d

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