1ip9

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[[Image:1ip9.png|left|200px]]
 
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{{STRUCTURE_1ip9| PDB=1ip9 | SCENE= }}
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==SOLUTION STRUCTURE OF THE PB1 DOMAIN OF BEM1P==
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<StructureSection load='1ip9' size='340' side='right'caption='[[1ip9]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ip9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IP9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ip9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ip9 OCA], [https://pdbe.org/1ip9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ip9 RCSB], [https://www.ebi.ac.uk/pdbsum/1ip9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ip9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BEM1_YEAST BEM1_YEAST] Necessary for cell polarization during vegetative growth. May link the cytoskeleton to morphogenic determinants on the cell surface.<ref>PMID:17460121</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/1ip9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ip9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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PB1 domains are novel protein modules capable of binding to target proteins that contain PC motifs. We report here the NMR structure and ligand-binding site of the PB1 domain of the cell polarity establishment protein, Bem1p. In addition, we identify the topology of the PC motif-containing region of Cdc24p by NMR, another cell polarity establishment protein that interacts with Bem1p. The PC motif-containing region is a structural domain offering a scaffold to the PC motif. The chemical shift perturbation experiment and the mutagenesis study show that the PC motif is a major structural element that binds to the PB1 domain. A structural database search reveals close similarity between the Bem1p PB1 domain and the c-Raf1 Ras-binding domain. However, these domains are functionally distinct from each other.
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===SOLUTION STRUCTURE OF THE PB1 DOMAIN OF BEM1P===
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Structure and ligand recognition of the PB1 domain: a novel protein module binding to the PC motif.,Terasawa H, Noda Y, Ito T, Hatanaka H, Ichikawa S, Ogura K, Sumimoto H, Inagaki F EMBO J. 2001 Aug 1;20(15):3947-56. PMID:11483498<ref>PMID:11483498</ref>
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{{ABSTRACT_PUBMED_11483498}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1ip9" style="background-color:#fffaf0;"></div>
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[[1ip9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IP9 OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:011483498</ref><references group="xtra"/>
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Hatanaka, H.]]
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[[Category: Hatanaka H]]
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[[Category: Ichikawa, S.]]
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[[Category: Ichikawa S]]
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[[Category: Inagaki, F.]]
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[[Category: Inagaki F]]
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[[Category: Ito, T.]]
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[[Category: Ito T]]
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[[Category: Noda, Y.]]
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[[Category: Noda Y]]
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[[Category: Ogura, K.]]
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[[Category: Ogura K]]
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[[Category: Sumimoto, H.]]
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[[Category: Sumimoto H]]
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[[Category: Terasawa, H.]]
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[[Category: Terasawa H]]
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[[Category: Signaling protein]]
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[[Category: Ubiquitin alpha/beta roll]]
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Current revision

SOLUTION STRUCTURE OF THE PB1 DOMAIN OF BEM1P

PDB ID 1ip9

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