1j1j

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[[Image:1j1j.png|left|200px]]
 
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{{STRUCTURE_1j1j| PDB=1j1j | SCENE= }}
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==Crystal Structure of human Translin==
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<StructureSection load='1j1j' size='340' side='right'caption='[[1j1j]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1j1j]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J1J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j1j OCA], [https://pdbe.org/1j1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j1j RCSB], [https://www.ebi.ac.uk/pdbsum/1j1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j1j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TSN_HUMAN TSN_HUMAN] DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.<ref>PMID:9111049</ref> <ref>PMID:21552258</ref> Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.<ref>PMID:9111049</ref> <ref>PMID:21552258</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j1/1j1j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j1j ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of human translin at 2.2 A resolution is reported in space group C222(1). Translin forms a tetramer in the asymmetric unit. Although the monomer structure is almost the same as the crystal structure of murine translin in space group P2(1)2(1)2, the relative positions of the tetramers differ between the human and murine translins. This suggests that the multimerization of translin is flexible; the flexibility may be related to the binding to DNA/RNA.
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===Crystal Structure of human Translin===
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Structure of human translin at 2.2 A resolution.,Sugiura I, Sasaki C, Hasegawa T, Kohno T, Sugio S, Moriyama H, Kasai M, Matsuzaki T Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):674-9. Epub 2004, Mar 23. PMID:15039555<ref>PMID:15039555</ref>
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{{ABSTRACT_PUBMED_15039555}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1j1j" style="background-color:#fffaf0;"></div>
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[[1j1j]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J1J OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:015039555</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hasegawa, T.]]
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[[Category: Large Structures]]
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[[Category: Kasai, M.]]
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[[Category: Hasegawa T]]
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[[Category: Kohno, T.]]
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[[Category: Kasai M]]
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[[Category: Matsuzaki, T.]]
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[[Category: Kohno T]]
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[[Category: Moriyama, H.]]
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[[Category: Matsuzaki T]]
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[[Category: Sasaki, C.]]
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[[Category: Moriyama H]]
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[[Category: Sugio, S.]]
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[[Category: Sasaki C]]
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[[Category: Sugiura, I.]]
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[[Category: Sugio S]]
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[[Category: Dna binding protein]]
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[[Category: Sugiura I]]
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[[Category: Rna binding protein]]
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[[Category: Ssdna binding protein]]
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[[Category: Testis/brain rna binding protein]]
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Current revision

Crystal Structure of human Translin

PDB ID 1j1j

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