4ew4

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[[Image:4ew4.png|left|200px]]
 
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{{STRUCTURE_4ew4| PDB=4ew4 | SCENE= }}
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==mouse MBD4 glycosylase domain in complex with DNA containing a ribose sugar==
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<StructureSection load='4ew4' size='340' side='right'caption='[[4ew4]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ew4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EW4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.791&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ew4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ew4 OCA], [https://pdbe.org/4ew4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ew4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ew4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ew4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MBD4_MOUSE MBD4_MOUSE] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
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===mouse MBD4 glycosylase domain in complex with DNA containing a ribose sugar===
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==See Also==
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*[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]]
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{{ABSTRACT_PUBMED_22740654}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[4ew4]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EW4 OCA].
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==Reference==
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<ref group="xtra">PMID:022740654</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Cheng, X.]]
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[[Category: Synthetic construct]]
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[[Category: Hashimoto, H.]]
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[[Category: Cheng X]]
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[[Category: Zhang, X.]]
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[[Category: Hashimoto H]]
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[[Category: Dna glycosylase]]
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[[Category: Zhang X]]
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[[Category: Helix-hairpin-helix]]
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[[Category: Hydrolase-dna complex]]
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[[Category: N-glycosidic bond]]
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[[Category: Stable intermediate]]
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Current revision

mouse MBD4 glycosylase domain in complex with DNA containing a ribose sugar

PDB ID 4ew4

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