1j0w

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[[Image:1j0w.png|left|200px]]
 
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{{STRUCTURE_1j0w| PDB=1j0w | SCENE= }}
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==Crystal Structure Analysis of the Dok-5 PTB Domain==
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<StructureSection load='1j0w' size='340' side='right'caption='[[1j0w]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal Structure Analysis of the Dok-5 PTB Domain===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1j0w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1J0W FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[1j0w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J0W OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1j0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j0w OCA], [https://pdbe.org/1j0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1j0w RCSB], [https://www.ebi.ac.uk/pdbsum/1j0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1j0w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DOK5_HUMAN DOK5_HUMAN] DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j0/1j0w_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1j0w ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Transferase]]
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[[Category: Large Structures]]
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[[Category: Ding, Y.]]
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[[Category: Ding Y]]
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[[Category: Qiang, B Q.]]
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[[Category: Qiang BQ]]
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[[Category: Rao, Z H.]]
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[[Category: Rao ZH]]
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[[Category: Shi, N.]]
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[[Category: Shi N]]
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[[Category: Yuan, J G.]]
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[[Category: Yuan JG]]
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[[Category: Alfa helix]]
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[[Category: Beta strand]]
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[[Category: Transferase]]
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Current revision

Crystal Structure Analysis of the Dok-5 PTB Domain

PDB ID 1j0w

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OCA

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