1r8i

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[[Image:1r8i.jpg|left|200px]]<br /><applet load="1r8i" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1r8i, resolution 3.00&Aring;" />
 
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'''Crystal structure of TraC'''<br />
 
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==Overview==
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==Crystal structure of TraC==
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Type IV secretion systems mediate intercellular transfer of macro-molecules via a mechanism ancestrally related to that of bacterial conjugation machineries. TraC of the IncN plasmid pKM101 belongs to the VirB5 family of proteins, an essential component of most type IV secretion systems. Here, we present the structure of TraC. VirB5/TraC is a single domain protein, which consists of a three helix bundle and a loose globular appendage. Structure-based site-directed mutagenesis followed by functional studies indicates that VirB5 proteins participate in protein-protein interactions important for pilus assembly and function.
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<StructureSection load='1r8i' size='340' side='right'caption='[[1r8i]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1r8i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R8I FirstGlance]. <br>
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1R8I is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R8I OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r8i OCA], [https://pdbe.org/1r8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r8i RCSB], [https://www.ebi.ac.uk/pdbsum/1r8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r8i ProSAT]</span></td></tr>
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==Reference==
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</table>
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Structural and functional characterization of the VirB5 protein from the type IV secretion system encoded by the conjugative plasmid pKM101., Yeo HJ, Yuan Q, Beck MR, Baron C, Waksman G, Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15947-52. Epub 2003 Dec 12. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14673074 14673074]
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== Function ==
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[https://www.uniprot.org/uniprot/Q9L6G5_ECOLX Q9L6G5_ECOLX]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r8/1r8i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r8i ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Baron, C.]]
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[[Category: Baron C]]
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[[Category: Beck, M R.]]
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[[Category: Beck MR]]
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[[Category: Waksman, G.]]
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[[Category: Waksman G]]
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[[Category: Yeo, H J.]]
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[[Category: Yeo H-J]]
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[[Category: Yuan, Q.]]
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[[Category: Yuan Q]]
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[[Category: helical bundle]]
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[[Category: trac]]
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[[Category: virb5]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:48:20 2008''
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Current revision

Crystal structure of TraC

PDB ID 1r8i

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