1rau
From Proteopedia
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| - | [[Image:1rau.gif|left|200px]]<br /><applet load="1rau" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1rau" /> | ||
| - | '''SOLUTION STRUCTURE OF AN UNUSUALLY STABLE RNA TETRAPLEX CONTAINING G-AND U-QUARTET STRUCTURES'''<br /> | ||
| - | == | + | ==SOLUTION STRUCTURE OF AN UNUSUALLY STABLE RNA TETRAPLEX CONTAINING G-AND U-QUARTET STRUCTURES== |
| + | <StructureSection load='1rau' size='340' side='right'caption='[[1rau]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1rau]] is a 4 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RAU FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rau OCA], [https://pdbe.org/1rau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rau RCSB], [https://www.ebi.ac.uk/pdbsum/1rau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rau ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
A model for the solution structure of an RNA tetraplex, (rUGGGGU)4, has been obtained by two-dimensional NMR spectroscopy and molecular dynamics. The molecule is parallel stranded and Hoogsteen base-paired in 50 mM KCl, and it is so stable that three of its six imino protons have exchange half-lives measured in days at 40 degrees C. The tetraplex is stabilized by base stacking and by the hydrogen bonds in four G quartets and at least one U quartet. This is the first indication of the existence of U-quartet structures of which we are aware. | A model for the solution structure of an RNA tetraplex, (rUGGGGU)4, has been obtained by two-dimensional NMR spectroscopy and molecular dynamics. The molecule is parallel stranded and Hoogsteen base-paired in 50 mM KCl, and it is so stable that three of its six imino protons have exchange half-lives measured in days at 40 degrees C. The tetraplex is stabilized by base stacking and by the hydrogen bonds in four G quartets and at least one U quartet. This is the first indication of the existence of U-quartet structures of which we are aware. | ||
| - | + | Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures.,Cheong C, Moore PB Biochemistry. 1992 Sep 15;31(36):8406-14. PMID:1382577<ref>PMID:1382577</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 1rau" style="background-color:#fffaf0;"></div> |
| - | [[Category: Cheong | + | == References == |
| - | [[Category: Moore | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | + | [[Category: Cheong C]] | |
| - | + | [[Category: Moore PB]] | |
Current revision
SOLUTION STRUCTURE OF AN UNUSUALLY STABLE RNA TETRAPLEX CONTAINING G-AND U-QUARTET STRUCTURES
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