2x7h

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[[Image:2x7h.png|left|200px]]
 
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{{STRUCTURE_2x7h| PDB=2x7h | SCENE= }}
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==Crystal structure of the human MGC45594 gene product in complex with fenoprofen==
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<StructureSection load='2x7h' size='340' side='right'caption='[[2x7h]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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===Crystal structure of the human MGC45594 gene product in complex with fenoprofen===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2x7h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X7H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=PFN:FENOPROFEN'>PFN</scene></td></tr>
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[[2x7h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X7H OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x7h OCA], [https://pdbe.org/2x7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x7h RCSB], [https://www.ebi.ac.uk/pdbsum/2x7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x7h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PTGR3_HUMAN PTGR3_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.[UniProtKB:Q8BGC4]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Bountra, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Chaikuad, A.]]
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[[Category: Bountra C]]
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[[Category: Delft, F Von.]]
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[[Category: Chaikuad A]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Niesen, F.]]
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[[Category: Niesen F]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann U]]
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[[Category: Pike, A C.W.]]
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[[Category: Pike ACW]]
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[[Category: Shafqat, N.]]
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[[Category: Shafqat N]]
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[[Category: Smee, C.]]
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[[Category: Smee C]]
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[[Category: Ugochukwu, E.]]
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[[Category: Ugochukwu E]]
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[[Category: Vollmar, M.]]
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[[Category: Vollmar M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Yue, W W.]]
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[[Category: Yue WW]]
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[[Category: Oxidoreductase]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of the human MGC45594 gene product in complex with fenoprofen

PDB ID 2x7h

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