2q80

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[[Image:2q80.png|left|200px]]
 
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{{STRUCTURE_2q80| PDB=2q80 | SCENE= }}
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==Crystal structure of human geranylgeranyl pyrophosphate synthase bound to GGPP==
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<StructureSection load='2q80' size='340' side='right'caption='[[2q80]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2q80]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2fvi 2fvi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q80 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q80 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GRG:GERANYLGERANYL+DIPHOSPHATE'>GRG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q80 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q80 OCA], [https://pdbe.org/2q80 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q80 RCSB], [https://www.ebi.ac.uk/pdbsum/2q80 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q80 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GGPPS_HUMAN GGPPS_HUMAN] Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q8/2q80_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q80 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human geranylgeranyl pyrophosphate synthase bound to GGPP===
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==See Also==
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*[[Geranylgeranyl pyrophosphate synthase 3D structures|Geranylgeranyl pyrophosphate synthase 3D structures]]
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{{ABSTRACT_PUBMED_16698791}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2q80]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2fvi 2fvi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q80 OCA].
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==Reference==
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<ref group="xtra">PMID:016698791</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C.]]
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[[Category: Large Structures]]
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[[Category: Bunkoczi, G.]]
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[[Category: Arrowsmith C]]
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[[Category: Delft, F von.]]
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[[Category: Bunkoczi G]]
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[[Category: Dunford, J E.]]
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[[Category: Dunford JE]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Kavanagh, K L.]]
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[[Category: Kavanagh KL]]
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[[Category: Oppermann, U.]]
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[[Category: Oppermann U]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Smee C]]
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[[Category: Smee, C.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: Isopentenyl transferase]]
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[[Category: Isoprenoid pathway]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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Current revision

Crystal structure of human geranylgeranyl pyrophosphate synthase bound to GGPP

PDB ID 2q80

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