This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2c46

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:05, 13 December 2023) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2c46.png|left|200px]]
 
-
{{STRUCTURE_2c46| PDB=2c46 | SCENE= }}
+
==CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase==
-
 
+
<StructureSection load='2c46' size='340' side='right'caption='[[2c46]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-
===CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2c46]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C46 FirstGlance]. <br>
-
 
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c46 OCA], [https://pdbe.org/2c46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c46 RCSB], [https://www.ebi.ac.uk/pdbsum/2c46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c46 ProSAT]</span></td></tr>
-
[[2c46]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C46 OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MCE1_HUMAN MCE1_HUMAN] Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/2c46_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c46 ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: MRNA guanylyltransferase]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C.]]
+
[[Category: Arrowsmith C]]
-
[[Category: Bunkoczi, G.]]
+
[[Category: Bunkoczi G]]
-
[[Category: Debreczeni, J.]]
+
[[Category: Debreczeni J]]
-
[[Category: Delft, F Von.]]
+
[[Category: Edwards A]]
-
[[Category: Edwards, A.]]
+
[[Category: Gileadi O]]
-
[[Category: Gileadi, O.]]
+
[[Category: Johansson C]]
-
[[Category: Johansson, C.]]
+
[[Category: Knapp S]]
-
[[Category: Knapp, S.]]
+
[[Category: Longman E]]
-
[[Category: Longman, E.]]
+
[[Category: SavitskySmee P]]
-
[[Category: Savitskysmee, P.]]
+
[[Category: Smee C]]
-
[[Category: Smee, C.]]
+
[[Category: Sundstrom M]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Ugochukwu E]]
-
[[Category: Ugochukwu, E.]]
+
[[Category: Weigelt J]]
-
[[Category: Weigelt, J.]]
+
[[Category: Von Delft F]]
-
[[Category: Hydrolase]]
+
-
[[Category: Mrna processing]]
+
-
[[Category: Multifunctional enzyme]]
+
-
[[Category: Nucleotidyltransferase]]
+
-
[[Category: Phosphatase]]
+
-
[[Category: Transferase]]
+

Current revision

CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase

PDB ID 2c46

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2c46"
Personal tools