4h6x

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[[Image:4h6x.png|left|200px]]
 
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{{STRUCTURE_4h6x| PDB=4h6x | SCENE= }}
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==Structure of Patellamide maturation protease PatG==
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<StructureSection load='4h6x' size='340' side='right'caption='[[4h6x]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4h6x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Prochloron_didemni Prochloron didemni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H6X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h6x OCA], [https://pdbe.org/4h6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h6x RCSB], [https://www.ebi.ac.uk/pdbsum/4h6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h6x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q52QJ1_PRODI Q52QJ1_PRODI]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Cyanobactins, a class of ribosomally encoded macrocylic natural products, are biosynthesized through the proteolytic processing and subsequent N-C macrocylization of ribosomal peptide precursors. Macrocylization occurs through a two-step process in which the first protease (PatA) removes the amino terminal flanking sequence from the precursor to yield a free N terminus of the precursor peptide, and the second protease (PatG) removes the C-terminal flanking sequence and then catalyzes the transamidation reaction to yield an N-C cyclized product. Here, we present the crystal structures of the protease domains of PatA and PatG from the patellamide cluster and of PagA from the prenylagaramide cluster. A comparative structural and biochemical analysis of the transamidating PatG protease reveals the presence of a unique structural element distinct from canonical subtilisin proteases, which may facilitate the N-C macrocylization of the peptide substrate.
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===Structure of Patellamide maturation protease PatG===
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Structures of cyanobactin maturation enzymes define a family of transamidating proteases.,Agarwal V, Pierce E, McIntosh J, Schmidt EW, Nair SK Chem Biol. 2012 Nov 21;19(11):1411-22. doi: 10.1016/j.chembiol.2012.09.012. PMID:23177196<ref>PMID:23177196</ref>
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{{ABSTRACT_PUBMED_23177196}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 4h6x" style="background-color:#fffaf0;"></div>
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[[4h6x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Prochloron_didemni Prochloron didemni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H6X OCA].
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Prochloron didemni]]
[[Category: Prochloron didemni]]
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[[Category: Agarwal, V.]]
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[[Category: Agarwal V]]
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[[Category: Nair, S K.]]
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[[Category: Nair SK]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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Current revision

Structure of Patellamide maturation protease PatG

PDB ID 4h6x

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