3w1z
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3w1z is ON HOLD until Paper Publication Authors: Hanazono, Y., Takeda, K., Akiyama, N., Aikawa, Y., Miki, K. Description: Heat shock protein 16.0 f...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Heat shock protein 16.0 from Schizosaccharomyces pombe== | |
| + | <StructureSection load='3w1z' size='340' side='right'caption='[[3w1z]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3w1z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3W1Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.401Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3w1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w1z OCA], [https://pdbe.org/3w1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3w1z RCSB], [https://www.ebi.ac.uk/pdbsum/3w1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3w1z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HSP16_SCHPO HSP16_SCHPO] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Small heat shock proteins (sHsps) play a role in preventing the fatal aggregation of denatured proteins in the presence of stresses. The sHsps exist as monodisperse oligomers in their resting state. Because the hydrophobic N-terminal regions of sHsps are possible interaction sites for denatured proteins, the manner of assembly of the oligomer is critical for the activation and inactivation mechanisms. Here, we report the oligomer architecture of SpHsp16.0 from Schizosaccharomyces pombe determined with X-ray crystallography and small angle X-ray scattering. Both results indicate that eight dimers of SpHsp16.0 form an elongated sphere with 422 symmetry. The monomers show nonequivalence in the interaction with neighboring monomers and conformations of the N- and C-terminal regions. Variants for the N-terminal phenylalanine residues indicate that the oligomer formation ability is highly correlated with chaperone activity. Structural and biophysical results are discussed in terms of their possible relevance to the activation mechanism of SpHsp16.0. | ||
| - | + | Nonequivalence Observed for the 16-Meric Structure of a Small Heat Shock Protein, SpHsp16.0, from Schizosaccharomyces pombe.,Hanazono Y, Takeda K, Oka T, Abe T, Tomonari T, Akiyama N, Aikawa Y, Yohda M, Miki K Structure. 2013 Feb 5;21(2):220-8. doi: 10.1016/j.str.2012.11.015. Epub 2012 Dec , 27. PMID:23273429<ref>PMID:23273429</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 3w1z" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Schizosaccharomyces pombe 972h-]] | ||
| + | [[Category: Aikawa Y]] | ||
| + | [[Category: Akiyama N]] | ||
| + | [[Category: Hanazono Y]] | ||
| + | [[Category: Miki K]] | ||
| + | [[Category: Takeda K]] | ||
Current revision
Heat shock protein 16.0 from Schizosaccharomyces pombe
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