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1reg

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[[Image:1reg.gif|left|200px]]<br /><applet load="1reg" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1reg, resolution 1.9&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE T4 REGA TRANSLATIONAL REGULATOR PROTEIN AT 1.9 ANGSTROMS RESOLUTION'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF THE T4 REGA TRANSLATIONAL REGULATOR PROTEIN AT 1.9 ANGSTROMS RESOLUTION==
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The translational regulator protein regA is encoded by the T4 bacteriophage and binds to a region of messenger RNA (mRNA) that includes the initiator codon. RegA is unusual in that it represses the translation of about 35 early T4 mRNAs but does not affect nearly 200 other mRNAs. The crystal structure of regA was determined at 1.9 A resolution; the protein was shown to have an alpha-helical core and two regions with antiparallel beta sheets. One of these beta sheets has four antiparallel strands and has some sequence homology to RNP-1 and RNP-2, which are believed to be RNA-binding motifs and are found in a number of known RNA-binding proteins. Structurally guided mutants may help to uncover the basis for this variety of RNA interaction.
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<StructureSection load='1reg' size='340' side='right'caption='[[1reg]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1reg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1REG FirstGlance]. <br>
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1REG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacteriophage_t4 Bacteriophage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1REG OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1reg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1reg OCA], [https://pdbe.org/1reg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1reg RCSB], [https://www.ebi.ac.uk/pdbsum/1reg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1reg ProSAT]</span></td></tr>
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==Reference==
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</table>
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Crystal structure of the T4 regA translational regulator protein at 1.9 A resolution., Kang C, Chan R, Berger I, Lockshin C, Green L, Gold L, Rich A, Science. 1995 May 26;268(5214):1170-3. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7761833 7761833]
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== Function ==
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[[Category: Bacteriophage t4]]
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[https://www.uniprot.org/uniprot/REGA_BPT4 REGA_BPT4] Controls the translation of a number of proteins (such as regA itself, rIIB and at least 35 others) by binding to their mRNA.
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[[Category: Single protein]]
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== Evolutionary Conservation ==
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[[Category: Kang, C.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Rich, A.]]
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Check<jmol>
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[[Category: translational regulator protein]]
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/re/1reg_consurf.spt"</scriptWhenChecked>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:50:02 2008''
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1reg ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Escherichia virus T4]]
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[[Category: Large Structures]]
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[[Category: Kang C]]
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[[Category: Rich A]]

Current revision

CRYSTAL STRUCTURE OF THE T4 REGA TRANSLATIONAL REGULATOR PROTEIN AT 1.9 ANGSTROMS RESOLUTION

PDB ID 1reg

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