1k0s

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[[Image:1k0s.png|left|200px]]
 
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{{STRUCTURE_1k0s| PDB=1k0s | SCENE= }}
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==Solution structure of the chemotaxis protein CheW from the thermophilic organism Thermotoga maritima==
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<StructureSection load='1k0s' size='340' side='right'caption='[[1k0s]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1k0s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K0S FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k0s OCA], [https://pdbe.org/1k0s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k0s RCSB], [https://www.ebi.ac.uk/pdbsum/1k0s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k0s ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CHEW_THEMA CHEW_THEMA] Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k0/1k0s_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k0s ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Using protein from the hyperthermophile Thermotoga maritima, we have determined the solution structure of CheW, an essential component in the formation of the bacterial chemotaxis signaling complex. The overall fold is similar to the regulatory domain of the chemotaxis kinase CheA. In addition, interactions of CheW with CheA were monitored by nuclear magnetic resonance (NMR) techniques. The chemical shift perturbation data show the probable contacts that CheW makes with CheA. In combination with previous genetic data, the structure also suggests a possible binding site for the chemotaxis receptor. These results provide a structural basis for a model in which CheW acts as a molecular bridge between CheA and the cytoplasmic tails of the receptor.
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===Solution structure of the chemotaxis protein CheW from the thermophilic organism Thermotoga maritima===
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The solution structure and interactions of CheW from Thermotoga maritima.,Griswold IJ, Zhou H, Matison M, Swanson RV, McIntosh LP, Simon MI, Dahlquist FW Nat Struct Biol. 2002 Feb;9(2):121-5. PMID:11799399<ref>PMID:11799399</ref>
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{{ABSTRACT_PUBMED_11799399}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1k0s" style="background-color:#fffaf0;"></div>
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[[1k0s]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0S OCA].
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==See Also==
==See Also==
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*[[Chemotaxis protein|Chemotaxis protein]]
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*[[Chemotaxis protein 3D structures|Chemotaxis protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:011799399</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: Dahlquist, F W.]]
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[[Category: Dahlquist FW]]
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[[Category: Griswold, I J.]]
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[[Category: Griswold IJ]]
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[[Category: Simon, M I.]]
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[[Category: Simon MI]]
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[[Category: Swanson, R V.]]
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[[Category: Swanson RV]]
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[[Category: Zhou, H.]]
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[[Category: Zhou H]]
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[[Category: Chew]]
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[[Category: Signaling protein]]
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Current revision

Solution structure of the chemotaxis protein CheW from the thermophilic organism Thermotoga maritima

PDB ID 1k0s

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