1jac
From Proteopedia
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| - | [[Image:1jac.png|left|200px]] | ||
| - | + | ==A NOVEL MODE OF CARBOHYDRATE RECOGNITION IN JACALIN, A MORACEAE PLANT LECTIN WITH A BETA-PRISM== | |
| + | <StructureSection load='1jac' size='340' side='right'caption='[[1jac]], [[Resolution|resolution]] 2.43Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1jac]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Artocarpus_heterophyllus Artocarpus heterophyllus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JAC FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMG:ALPHA-METHYL-D-GALACTOSIDE'>AMG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jac OCA], [https://pdbe.org/1jac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jac RCSB], [https://www.ebi.ac.uk/pdbsum/1jac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jac ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LECA_ARTIN LECA_ARTIN] D-galactose-specific lectin, binds the T-antigen structure Gal-beta1,3-GalNAc (Thomsen-Friedenreich-antigen-specific lectin). Potent and selective stimulant of distinct T- and B-cell functions. Shows a unique ability to specifically recognize IgA-1 from human serum. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ja/1jac_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jac ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | == | + | ==See Also== |
| - | + | *[[Agglutinin 3D structures|Agglutinin 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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| - | [[ | + | |
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[[Category: Artocarpus heterophyllus]] | [[Category: Artocarpus heterophyllus]] | ||
| - | [[Category: Banerjee | + | [[Category: Large Structures]] |
| - | [[Category: Sankaranarayanan | + | [[Category: Banerjee R]] |
| - | [[Category: Sekar | + | [[Category: Sankaranarayanan R]] |
| - | [[Category: Sharma | + | [[Category: Sekar K]] |
| - | [[Category: Surolia | + | [[Category: Sharma V]] |
| - | [[Category: Vijayan | + | [[Category: Surolia A]] |
| - | + | [[Category: Vijayan M]] | |
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Current revision
A NOVEL MODE OF CARBOHYDRATE RECOGNITION IN JACALIN, A MORACEAE PLANT LECTIN WITH A BETA-PRISM
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