1jhn
From Proteopedia
(Difference between revisions)
m (Protected "1jhn" [edit=sysop:move=sysop]) |
|||
| (7 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:1jhn.png|left|200px]] | ||
| - | + | ==Crystal Structure of the Lumenal Domain of Calnexin== | |
| - | + | <StructureSection load='1jhn' size='340' side='right'caption='[[1jhn]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1jhn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JHN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jhn OCA], [https://pdbe.org/1jhn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jhn RCSB], [https://www.ebi.ac.uk/pdbsum/1jhn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jhn ProSAT]</span></td></tr> |
| - | [[1jhn]] is a 1 chain structure with sequence from [ | + | </table> |
| - | + | == Function == | |
| - | == | + | [https://www.uniprot.org/uniprot/CALX_CANLF CALX_CANLF] Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse (By similarity). |
| - | < | + | == Evolutionary Conservation == |
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/1jhn_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jhn ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Canis lupus familiaris]] | [[Category: Canis lupus familiaris]] | ||
| - | [[Category: Bergeron | + | [[Category: Large Structures]] |
| - | [[Category: Borisova | + | [[Category: Bergeron JM]] |
| - | [[Category: Cygler | + | [[Category: Borisova S]] |
| - | [[Category: Hahn | + | [[Category: Cygler M]] |
| - | [[Category: Li | + | [[Category: Hahn M]] |
| - | [[Category: Schrag | + | [[Category: Li Y]] |
| - | [[Category: Thomas | + | [[Category: Schrag JD]] |
| - | + | [[Category: Thomas DY]] | |
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of the Lumenal Domain of Calnexin
| |||||||||||
