1jd5

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[[Image:1jd5.png|left|200px]]
 
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{{STRUCTURE_1jd5| PDB=1jd5 | SCENE= }}
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==Crystal Structure of DIAP1-BIR2/GRIM==
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<StructureSection load='1jd5' size='340' side='right'caption='[[1jd5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Crystal Structure of DIAP1-BIR2/GRIM===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jd5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JD5 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11511363}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jd5 OCA], [https://pdbe.org/1jd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jd5 RCSB], [https://www.ebi.ac.uk/pdbsum/1jd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jd5 ProSAT]</span></td></tr>
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[[1jd5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JD5 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/DIAP1_DROME DIAP1_DROME] Anti-apoptotic protein which functions as a caspase regulator, using its E3 ubiquitin-protein ligase activity to smother caspase activity. Binds, ubiquitinates and inactivates initiator caspase Dronc, and effector caspases Drice and Dcp-1. Acts as a Nedd8-E3 ubiquitin-protein ligase for Drice. Suppresses apoptosis by targeting the apoptosome for ubiquitination and inactivation. Plays an important role in cell motility. Overexpression suppresses rpr and hid-dependent cell death in the eye. Interaction of Diap1 with Dronc is required to suppress Dronc-mediated cell death through Diap1-mediated ubiquitination of Dronc. Acts as a positive regulator of Wnt signaling.<ref>PMID:14517550</ref> <ref>PMID:17397804</ref> <ref>PMID:18259196</ref> <ref>PMID:21145488</ref> <ref>PMID:22304967</ref> <ref>PMID:8548811</ref>
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<ref group="xtra">PMID:011511363</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jd/1jd5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jd5 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Chai, J.]]
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[[Category: Large Structures]]
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[[Category: Cocina, A E.]]
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[[Category: Chai J]]
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[[Category: Hay, B A.]]
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[[Category: Cocina AE]]
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[[Category: Shi, Y.]]
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[[Category: Hay BA]]
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[[Category: Wu, J W.]]
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[[Category: Shi Y]]
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[[Category: Apoptosis]]
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[[Category: Wu JW]]
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[[Category: Caspase activation]]
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[[Category: Drosophila]]
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[[Category: Grim]]
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[[Category: Hydrolase-peptide complex]]
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[[Category: Iap]]
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Current revision

Crystal Structure of DIAP1-BIR2/GRIM

PDB ID 1jd5

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