This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1jy8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1jy8" [edit=sysop:move=sysop])
Current revision (07:42, 7 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1jy8.png|left|200px]]
 
-
{{STRUCTURE_1jy8| PDB=1jy8 | SCENE= }}
+
==2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF)==
 +
<StructureSection load='1jy8' size='340' side='right'caption='[[1jy8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1jy8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JY8 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=CDI:2C-METHYL-D-ERYTHRITOL+2,4-CYCLODIPHOSPHATE'>CDI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jy8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jy8 OCA], [https://pdbe.org/1jy8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jy8 RCSB], [https://www.ebi.ac.uk/pdbsum/1jy8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jy8 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ISPF_ECOLI ISPF_ECOLI] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). Also converts 4-diphosphocytidyl-2-C-methyl-D-erythritol into 2-C-methyl-D-erythritol 3,4-cyclophosphate and CMP.<ref>PMID:10694574</ref> <ref>PMID:22839733</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/1jy8_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jy8 ConSurf].
 +
<div style="clear:both"></div>
-
===2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF)===
+
==See Also==
-
 
+
*[[MECDP synthase 3D structures|MECDP synthase 3D structures]]
-
{{ABSTRACT_PUBMED_11829504}}
+
== References ==
-
 
+
<references/>
-
==About this Structure==
+
__TOC__
-
[[1jy8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JY8 OCA].
+
</StructureSection>
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:011829504</ref><references group="xtra"/>
+
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
-
[[Category: Bacher, A.]]
+
[[Category: Large Structures]]
-
[[Category: Eisenreich, W.]]
+
[[Category: Bacher A]]
-
[[Category: Gerhardt, S.]]
+
[[Category: Eisenreich W]]
-
[[Category: Hecht, S.]]
+
[[Category: Gerhardt S]]
-
[[Category: Kaiser, J.]]
+
[[Category: Hecht S]]
-
[[Category: Rohdich, F.]]
+
[[Category: Kaiser J]]
-
[[Category: Steinbacher, S.]]
+
[[Category: Rohdich F]]
-
[[Category: Wungsintaweekul, J.]]
+
[[Category: Steinbacher S]]
-
[[Category: Biosynthetic protein]]
+
[[Category: Wungsintaweekul J]]
-
[[Category: Drug design]]
+
-
[[Category: Isoprenoid biosynthesis]]
+
-
[[Category: Malaria]]
+
-
[[Category: Terpene]]
+

Current revision

2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (IspF)

PDB ID 1jy8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jy8"
Personal tools