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1jmu

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[[Image:1jmu.png|left|200px]]
 
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{{STRUCTURE_1jmu| PDB=1jmu | SCENE= }}
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==Crystal Structure of the Reovirus mu1/sigma3 Complex==
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<StructureSection load='1jmu' size='340' side='right'caption='[[1jmu]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jmu]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JMU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jmu OCA], [https://pdbe.org/1jmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jmu RCSB], [https://www.ebi.ac.uk/pdbsum/1jmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jmu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MU1_REOVL MU1_REOVL] Major outer capsid protein involved in host cell membrane penetration. In the endocytic compartment, outer-capsid protein sigma-3 is removed by cathepsin proteases, which exposes the viral membrane-penetration protein mu-1. Both myristoylated peptides mu-1N and phi are released during infectious subvirion particles (ISVP) formation in the endosome. They associate with host membranes and mu-1N induces permeabilization and delivery of transcriptionally active viral particles into the host cell cytoplasm. Seems to induce apoptosis in the host cell.<ref>PMID:11007773</ref> <ref>PMID:15280481</ref> <ref>PMID:16912293</ref> <ref>PMID:17005655</ref> <ref>PMID:18369316</ref> The viral outer shell polypeptides, of which mu-1 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3.<ref>PMID:11007773</ref> <ref>PMID:15280481</ref> <ref>PMID:16912293</ref> <ref>PMID:17005655</ref> <ref>PMID:18369316</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jm/1jmu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jmu ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the Reovirus mu1/sigma3 Complex===
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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{{ABSTRACT_PUBMED_11832217}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1jmu]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Reovirus_sp. Reovirus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JMU OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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[[Category: Reovirus sp]]
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<ref group="xtra">PMID:011832217</ref><references group="xtra"/>
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[[Category: Harrison SC]]
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[[Category: Reovirus sp.]]
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[[Category: Liemann S]]
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[[Category: Harrison, S C.]]
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[[Category: Nibert ML]]
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[[Category: Liemann, S.]]
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[[Category: Nibert, M L.]]
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[[Category: Jelly roll]]
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[[Category: Protein-protein complex]]
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[[Category: Viral protein]]
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[[Category: Zinc finger]]
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Current revision

Crystal Structure of the Reovirus mu1/sigma3 Complex

PDB ID 1jmu

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