1jc6

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[[Image:1jc6.png|left|200px]]
 
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{{STRUCTURE_1jc6| PDB=1jc6 | SCENE= }}
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==SOLUTION STRUCTURE OF BUNGARUS FACIATUS IX, A KUNITZ-TYPE CHYMOTRYPSIN INHIBITOR==
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<StructureSection load='1jc6' size='340' side='right'caption='[[1jc6]]' scene=''>
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===SOLUTION STRUCTURE OF BUNGARUS FACIATUS IX, A KUNITZ-TYPE CHYMOTRYPSIN INHIBITOR===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1jc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bungarus_fasciatus Bungarus fasciatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JC6 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11562364}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jc6 OCA], [https://pdbe.org/1jc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jc6 RCSB], [https://www.ebi.ac.uk/pdbsum/1jc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jc6 ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1jc6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bungarus_fasciatus Bungarus fasciatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JC6 OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/VKT9_BUNFA VKT9_BUNFA] Dual-function toxin that inhibits both serine proteases (high activity on chymotrypsin (Ki = 18 nM), and low activity on elastase) and voltage-gated potassium channels Kv1.3/KCNA3 (IC(50) = 120.0 nM).<ref>PMID:11562364</ref> <ref>PMID:24243656</ref>
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==Reference==
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== Evolutionary Conservation ==
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<ref group="xtra">PMID:011562364</ref><references group="xtra"/>
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jc/1jc6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jc6 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bungarus fasciatus]]
[[Category: Bungarus fasciatus]]
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[[Category: Chen, C.]]
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[[Category: Large Structures]]
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[[Category: Chiou, S H.]]
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[[Category: Chen C]]
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[[Category: Hsu, C H.]]
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[[Category: Chiou SH]]
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[[Category: Su, N Y.]]
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[[Category: Hsu CH]]
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[[Category: Wu, S H.]]
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[[Category: Su NY]]
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[[Category: Bf ix]]
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[[Category: Wu SH]]
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[[Category: Chymotrypsin inhibitor]]
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[[Category: Kunitz inhibitor]]
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[[Category: Neurotoxin]]
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[[Category: Protease inhibitor]]
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[[Category: Snake venom]]
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[[Category: Solution structure]]
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[[Category: Toxin]]
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Current revision

SOLUTION STRUCTURE OF BUNGARUS FACIATUS IX, A KUNITZ-TYPE CHYMOTRYPSIN INHIBITOR

PDB ID 1jc6

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