1nqx

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[[Image:1nqx.png|left|200px]]
 
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{{STRUCTURE_1nqx| PDB=1nqx | SCENE= }}
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==Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 3-(7-hydroxy-8-ribityllumazine-6-yl)propionic acid==
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<StructureSection load='1nqx' size='340' side='right'caption='[[1nqx]], [[Resolution|resolution]] 1.82&Aring;' scene=''>
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===Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 3-(7-hydroxy-8-ribityllumazine-6-yl)propionic acid===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nqx]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NQX FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12684006}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RLP:3-(7-HYDROXY-8-RIBITYLLUMAZINE-6-YL)+PROPIONIC+ACID'>RLP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nqx OCA], [https://pdbe.org/1nqx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nqx RCSB], [https://www.ebi.ac.uk/pdbsum/1nqx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nqx ProSAT]</span></td></tr>
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[[1nqx]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NQX OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/RISB_AQUAE RISB_AQUAE] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.<ref>PMID:12603336</ref> <ref>PMID:11237620</ref>
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<ref group="xtra">PMID:012684006</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Category: Aquifex aeolicus]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Riboflavin synthase]]
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Check<jmol>
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[[Category: Bacher, A.]]
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<jmolCheckbox>
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[[Category: Cushman, M.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nq/1nqx_consurf.spt"</scriptWhenChecked>
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[[Category: Fischer, M.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Haase, I.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Ladenstein, R.]]
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</jmolCheckbox>
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[[Category: Meining, W.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nqx ConSurf].
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[[Category: Zhang, X.]]
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Aquifex aeolicus]]
[[Category: Aquifex aeolicus]]
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[[Category: Catalytic mechanism]]
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[[Category: Large Structures]]
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[[Category: Inhibitor complex]]
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[[Category: Bacher A]]
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[[Category: Lumazine synthase]]
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[[Category: Cushman M]]
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[[Category: Transferase]]
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[[Category: Fischer M]]
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[[Category: Vitamin biosynthesis]]
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[[Category: Haase I]]
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[[Category: Ladenstein R]]
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[[Category: Meining W]]
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[[Category: Zhang X]]

Current revision

Crystal Structure of Lumazine Synthase from Aquifex aeolicus in Complex with Inhibitor: 3-(7-hydroxy-8-ribityllumazine-6-yl)propionic acid

PDB ID 1nqx

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