1nj3

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[[Image:1nj3.png|left|200px]]
 
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{{STRUCTURE_1nj3| PDB=1nj3 | SCENE= }}
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==Structure and Ubiquitin Interactions of the Conserved NZF Domain of Npl4==
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<StructureSection load='1nj3' size='340' side='right'caption='[[1nj3]]' scene=''>
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===Structure and Ubiquitin Interactions of the Conserved NZF Domain of Npl4===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nj3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NJ3 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12644454}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nj3 OCA], [https://pdbe.org/1nj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nj3 RCSB], [https://www.ebi.ac.uk/pdbsum/1nj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nj3 ProSAT]</span></td></tr>
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[[1nj3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NJ3 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/NPL4_RAT NPL4_RAT] The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope.<ref>PMID:10811609</ref> <ref>PMID:11781570</ref> <ref>PMID:11740563</ref> <ref>PMID:14636562</ref> <ref>PMID:12411482</ref> <ref>PMID:12644454</ref>
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<ref group="xtra">PMID:012644454</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nj/1nj3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nj3 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Alam, S L.]]
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[[Category: Alam SL]]
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[[Category: Davis, D R.]]
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[[Category: Davis DR]]
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[[Category: Meyer, H H.]]
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[[Category: Meyer HH]]
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[[Category: Payne, M.]]
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[[Category: Payne M]]
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[[Category: Stemmler, T L.]]
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[[Category: Stemmler TL]]
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[[Category: Sundquist, W I.]]
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[[Category: Sundquist WI]]
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[[Category: Wang, B.]]
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[[Category: Wang B]]
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[[Category: Beta-ribbon]]
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[[Category: Npl4]]
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[[Category: Nzf domain]]
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[[Category: Protein binding]]
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[[Category: Rubredoxin knuckle]]
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[[Category: Ubiquitin]]
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[[Category: Zinc-finger]]
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Current revision

Structure and Ubiquitin Interactions of the Conserved NZF Domain of Npl4

PDB ID 1nj3

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