1m13

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[[Image:1m13.png|left|200px]]
 
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{{STRUCTURE_1m13| PDB=1m13 | SCENE= }}
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==Crystal Structure of the Human Pregane X Receptor Ligand Binding Domain in Complex with Hyperforin, a Constituent of St. John's Wort==
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<StructureSection load='1m13' size='340' side='right'caption='[[1m13]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1m13]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M13 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M13 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HYF:4-HYDROXY-5-ISOBUTYRYL-6-METHYL-1,3,7-TRIS-(3-METHYL-BUT-2-ENYL)-6-(4-METHYL-PENT-3-ENYL)-BICYCLO[3.3.1]NON-3-ENE-2,9-DIONE'>HYF</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m13 OCA], [https://pdbe.org/1m13 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m13 RCSB], [https://www.ebi.ac.uk/pdbsum/1m13 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m13 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NR1I2_HUMAN NR1I2_HUMAN] Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.<ref>PMID:9727070</ref> <ref>PMID:11668216</ref> <ref>PMID:11297522</ref> <ref>PMID:19297428</ref> <ref>PMID:12578355</ref> <ref>PMID:18768384</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m1/1m13_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m13 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the Human Pregane X Receptor Ligand Binding Domain in Complex with Hyperforin, a Constituent of St. John's Wort===
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==See Also==
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*[[Pregnane X receptor 3D structures|Pregnane X receptor 3D structures]]
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{{ABSTRACT_PUBMED_12578355}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1m13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M13 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:012578355</ref><ref group="xtra">PMID:012733986</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Davis-Searles, P R.]]
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[[Category: Large Structures]]
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[[Category: Kliewer, S A.]]
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[[Category: Davis-Searles PR]]
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[[Category: Lambert, M H.]]
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[[Category: Kliewer SA]]
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[[Category: Maglich, J M.]]
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[[Category: Lambert MH]]
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[[Category: Moore, L B.]]
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[[Category: Maglich JM]]
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[[Category: Noble, S M.]]
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[[Category: Moore LB]]
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[[Category: Redinbo, M R.]]
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[[Category: Noble SM]]
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[[Category: Watkins, R E.]]
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[[Category: Redinbo MR]]
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[[Category: Wisely, G B.]]
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[[Category: Watkins RE]]
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[[Category: Ligand binding domain]]
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[[Category: Wisely GB]]
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[[Category: Nuclear receptor]]
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[[Category: Protein-ligand complex]]
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[[Category: Transcription]]
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Current revision

Crystal Structure of the Human Pregane X Receptor Ligand Binding Domain in Complex with Hyperforin, a Constituent of St. John's Wort

PDB ID 1m13

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