1lx7

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[[Image:1lx7.png|left|200px]]
 
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{{STRUCTURE_1lx7| PDB=1lx7 | SCENE= }}
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==Structure of E. coli uridine phosphorylase at 2.0A==
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<StructureSection load='1lx7' size='340' side='right'caption='[[1lx7]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LX7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lx7 OCA], [https://pdbe.org/1lx7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lx7 RCSB], [https://www.ebi.ac.uk/pdbsum/1lx7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lx7 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1lx7 TOPSAN]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lx/1lx7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lx7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The 2.0 A crystal structure has been determined for Escherichia coli uridine phosphorylase (UP), an essential enzyme in nucleotide biosynthesis that catalyzes the phosphorolytic cleavage of the C-N glycosidic bond of uridine to ribose-1-phosphate and uracil. The structure determination of two independent monomers in the asymmetric unit revealed the residue composition and atomic details of the apo configurations of each active site. The native hexameric UP enzyme was revealed by applying threefold crystallographic symmetry to the contents of the asymmetric unit. The 2.0 A model reveals a closer structural relationship to other nucleotide phosphorylase enzymes than was previously appreciated.
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===Structure of E. coli uridine phosphorylase at 2.0A===
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Structure of Escherichia coli uridine phosphorylase at 2.0 A.,Burling FT, Kniewel R, Buglino JA, Chadha T, Beckwith A, Lima CD Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):73-6. Epub 2002 Dec, 19. PMID:12499542<ref>PMID:12499542</ref>
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{{ABSTRACT_PUBMED_12499542}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1lx7" style="background-color:#fffaf0;"></div>
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==About this Structure==
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==See Also==
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[[1lx7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LX7 OCA].
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*[[Uridine phosphorylase 3D structures|Uridine phosphorylase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:012499542</ref><references group="xtra"/>
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__TOC__
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[[Category: Escherichia coli]]
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</StructureSection>
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[[Category: Uridine phosphorylase]]
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[[Category: Large Structures]]
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[[Category: Beckwith, A.]]
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[[Category: Beckwith A]]
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[[Category: Buglino, J A.]]
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[[Category: Buglino JA]]
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[[Category: Burley, S K.]]
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[[Category: Burley SK]]
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[[Category: Burling, T.]]
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[[Category: Burling T]]
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[[Category: Chadna, T.]]
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[[Category: Chadna T]]
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[[Category: Kniewel, R.]]
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[[Category: Kniewel R]]
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[[Category: Lima, C D.]]
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[[Category: Lima CD]]
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[[Category: NYSGXRC, New York SGX Research Center for Structural Genomics.]]
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[[Category: New york sgx research center for structural genomic]]
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[[Category: Nucleotide metabolism]]
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[[Category: Nysgxrc]]
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[[Category: P12758]]
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[[Category: Phosphorylase]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Transferase]]
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[[Category: Udrpase]]
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Current revision

Structure of E. coli uridine phosphorylase at 2.0A

PDB ID 1lx7

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