1ksq

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[[Image:1ksq.png|left|200px]]
 
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{{STRUCTURE_1ksq| PDB=1ksq | SCENE= }}
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==NMR Study of the Third TB Domain from Latent Transforming Growth Factor-beta Binding Protein-1==
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<StructureSection load='1ksq' size='340' side='right'caption='[[1ksq]]' scene=''>
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===NMR Study of the Third TB Domain from Latent Transforming Growth Factor-beta Binding Protein-1===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ksq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KSQ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_14607119}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ksq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ksq OCA], [https://pdbe.org/1ksq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ksq RCSB], [https://www.ebi.ac.uk/pdbsum/1ksq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ksq ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1ksq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KSQ OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/LTBP1_HUMAN LTBP1_HUMAN] Autosomal recessive cutis laxa type 1. The disease is caused by variants affecting the gene represented in this entry.
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==Reference==
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== Function ==
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<ref group="xtra">PMID:014607119</ref><references group="xtra"/>
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[https://www.uniprot.org/uniprot/LTBP1_HUMAN LTBP1_HUMAN] Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742).<ref>PMID:15184403</ref> <ref>PMID:2022183</ref> <ref>PMID:22278742</ref> <ref>PMID:8617200</ref> <ref>PMID:8939931</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ks/1ksq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ksq ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Downing, A K.]]
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[[Category: Large Structures]]
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[[Category: Handford, P A.]]
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[[Category: Downing AK]]
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[[Category: Knott, V.]]
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[[Category: Handford PA]]
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[[Category: Lack, J.]]
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[[Category: Knott V]]
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[[Category: Rifkin, D B.]]
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[[Category: Lack J]]
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[[Category: Yuan, X.]]
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[[Category: O'leary JM]]
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[[Category: Leary, J M.O.]]
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[[Category: Rifkin DB]]
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[[Category: Lap]]
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[[Category: Yuan X]]
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[[Category: Latency associated propeptide]]
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[[Category: Latent transforming growth factor-beta binding protein-1]]
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[[Category: Ltbp-1]]
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[[Category: Protein binding]]
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[[Category: Tb domain]]
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[[Category: Tgf-beta]]
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Current revision

NMR Study of the Third TB Domain from Latent Transforming Growth Factor-beta Binding Protein-1

PDB ID 1ksq

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