1n83

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:53, 14 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1n83.png|left|200px]]
 
-
{{STRUCTURE_1n83| PDB=1n83 | SCENE= }}
+
==Crystal Structure of the complex between the Orphan Nuclear Hormone Receptor ROR(alpha)-LBD and Cholesterol==
-
 
+
<StructureSection load='1n83' size='340' side='right'caption='[[1n83]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
-
===Crystal Structure of the complex between the Orphan Nuclear Hormone Receptor ROR(alpha)-LBD and Cholesterol===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1n83]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N83 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_12467577}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n83 OCA], [https://pdbe.org/1n83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n83 RCSB], [https://www.ebi.ac.uk/pdbsum/1n83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n83 ProSAT]</span></td></tr>
-
[[1n83]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N83 OCA].
+
</table>
-
 
+
== Function ==
-
==Reference==
+
[https://www.uniprot.org/uniprot/RORA_HUMAN RORA_HUMAN] Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one of its derivatives.<ref>PMID:9862959</ref> <ref>PMID:11554739</ref> <ref>PMID:11053433</ref> <ref>PMID:14570920</ref> <ref>PMID:15790933</ref> <ref>PMID:15781255</ref> <ref>PMID:17512500</ref> <ref>PMID:18658046</ref> <ref>PMID:18005000</ref> <ref>PMID:12467577</ref>
-
<ref group="xtra">PMID:012467577</ref><references group="xtra"/>
+
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n8/1n83_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n83 ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Bitsch, F.]]
+
[[Category: Large Structures]]
-
[[Category: Delhon, I.]]
+
[[Category: Bitsch F]]
-
[[Category: Fournier, B.]]
+
[[Category: Delhon I]]
-
[[Category: Geiser, M.]]
+
[[Category: Fournier B]]
-
[[Category: Geisse, S.]]
+
[[Category: Geiser M]]
-
[[Category: Kallen, J A.]]
+
[[Category: Geisse S]]
-
[[Category: Schlaeppi, J M.]]
+
[[Category: Kallen JA]]
-
[[Category: Dna binding]]
+
[[Category: Schlaeppi JM]]
-
[[Category: Lipid binding protein]]
+
-
[[Category: Nuclear protein]]
+
-
[[Category: Receptor]]
+
-
[[Category: Three-layered alpha helical sandwich]]
+
-
[[Category: Transcription regulation]]
+

Current revision

Crystal Structure of the complex between the Orphan Nuclear Hormone Receptor ROR(alpha)-LBD and Cholesterol

PDB ID 1n83

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1n83"
Personal tools