1ng3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:56, 14 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1ng3.png|left|200px]]
 
-
{{STRUCTURE_1ng3| PDB=1ng3 | SCENE= }}
+
==Complex of ThiO (glycine oxidase) with acetyl-glycine==
-
 
+
<StructureSection load='1ng3' size='340' side='right'caption='[[1ng3]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-
===Complex of ThiO (glycine oxidase) with acetyl-glycine===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1ng3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NG3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NG3 FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_12627963}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AAC:ACETYLAMINO-ACETIC+ACID'>AAC</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ng3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ng3 OCA], [https://pdbe.org/1ng3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ng3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ng3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ng3 ProSAT]</span></td></tr>
-
[[1ng3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NG3 OCA].
+
</table>
-
 
+
== Function ==
-
==Reference==
+
[https://www.uniprot.org/uniprot/GLYOX_BACSU GLYOX_BACSU] Catalyzes the FAD-dependent oxidative deamination of various amines and D-amino acids to yield the corresponding alpha-keto acids, ammonia/amine, and hydrogen peroxide. Oxidizes sarcosine (N-methylglycine), N-ethylglycine and glycine (PubMed:9827558, PubMed:11744710, PubMed:19864430). Can also oxidize the herbicide glyphosate (N-phosphonomethylglycine) (PubMed:19864430). Displays lower activities on D-alanine, D-valine, D-proline and D-methionine (PubMed:9827558, PubMed:11744710). Does not act on L-amino acids and other D-amino acids (PubMed:9827558). Is essential for thiamine biosynthesis since the oxidation of glycine catalyzed by ThiO generates the glycine imine intermediate (dehydroglycine) required for the biosynthesis of the thiazole ring of thiamine pyrophosphate (PubMed:12627963).<ref>PMID:11744710</ref> <ref>PMID:12627963</ref> <ref>PMID:19864430</ref> <ref>PMID:9827558</ref>
-
<ref group="xtra">PMID:012627963</ref><references group="xtra"/>
+
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ng/1ng3_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ng3 ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
-
[[Category: Augustine, A.]]
+
[[Category: Large Structures]]
-
[[Category: Begley, T P.]]
+
[[Category: Augustine A]]
-
[[Category: Dorrestein, P C.]]
+
[[Category: Begley TP]]
-
[[Category: Ealick, S E.]]
+
[[Category: Dorrestein PC]]
-
[[Category: Park, J.]]
+
[[Category: Ealick SE]]
-
[[Category: Settembre, E C.]]
+
[[Category: Park J]]
-
[[Category: Flavoprotein]]
+
[[Category: Settembre EC]]
-
[[Category: Oxidase]]
+
-
[[Category: Oxidoreductase]]
+

Current revision

Complex of ThiO (glycine oxidase) with acetyl-glycine

PDB ID 1ng3

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ng3"
Personal tools