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1khx

From Proteopedia

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[[Image:1khx.png|left|200px]]
 
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{{STRUCTURE_1khx| PDB=1khx | SCENE= }}
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==Crystal structure of a phosphorylated Smad2==
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<StructureSection load='1khx' size='340' side='right'caption='[[1khx]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===Crystal structure of a phosphorylated Smad2===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1khx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KHX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KHX FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11779503}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1khx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1khx OCA], [https://pdbe.org/1khx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1khx RCSB], [https://www.ebi.ac.uk/pdbsum/1khx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1khx ProSAT]</span></td></tr>
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[[1khx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KHX OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/SMAD2_HUMAN SMAD2_HUMAN] Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.<ref>PMID:9892009</ref> <ref>PMID:16751101</ref> <ref>PMID:17327236</ref> <ref>PMID:16862174</ref> <ref>PMID:19289081</ref>
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<ref group="xtra">PMID:011779503</ref><ref group="xtra">PMID:018939858</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kh/1khx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1khx ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chai, J.]]
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[[Category: Large Structures]]
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[[Category: Fairman, R.]]
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[[Category: Chai J]]
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[[Category: Hu, M.]]
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[[Category: Fairman R]]
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[[Category: Huse, M.]]
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[[Category: Hu M]]
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[[Category: Kyin, S.]]
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[[Category: Huse M]]
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[[Category: Massague, J.]]
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[[Category: Kyin S]]
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[[Category: Muir, T W.]]
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[[Category: Massague J]]
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[[Category: Seoane, J.]]
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[[Category: Muir TW]]
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[[Category: Shi, Y.]]
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[[Category: Seoane J]]
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[[Category: Wu, J W.]]
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[[Category: Shi Y]]
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[[Category: Cancer]]
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[[Category: Wu J-W]]
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[[Category: Phosphorylation]]
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[[Category: Receptor kinase signaling]]
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[[Category: Smad2]]
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[[Category: Tgf-beta signaling]]
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[[Category: Transcription]]
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Current revision

Crystal structure of a phosphorylated Smad2

PDB ID 1khx

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