This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1mek

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1mek" [edit=sysop:move=sysop])
Current revision (08:35, 10 April 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1mek.png|left|200px]]
 
-
{{STRUCTURE_1mek| PDB=1mek | SCENE= }}
+
==HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 40 STRUCTURES==
-
 
+
<StructureSection load='1mek' size='340' side='right'caption='[[1mek]]' scene=''>
-
===HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 40 STRUCTURES===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1mek]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MEK FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_8672469}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
 
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mek FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mek OCA], [https://pdbe.org/1mek PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mek RCSB], [https://www.ebi.ac.uk/pdbsum/1mek PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mek ProSAT]</span></td></tr>
-
==About this Structure==
+
</table>
-
[[1mek]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MEK OCA].
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/PDIA1_HUMAN PDIA1_HUMAN] This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.<ref>PMID:10636893</ref> <ref>PMID:12485997</ref>
-
==Reference==
+
== Evolutionary Conservation ==
-
<ref group="xtra">PMID:008672469</ref><ref group="xtra">PMID:017530916</ref><references group="xtra"/>
+
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/me/1mek_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1mek ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Protein disulfide-isomerase]]
+
[[Category: Large Structures]]
-
[[Category: Creighton, T E.]]
+
[[Category: Creighton TE]]
-
[[Category: Darby, N J.]]
+
[[Category: Darby NJ]]
-
[[Category: Dijkstra, K.]]
+
[[Category: Dijkstra K]]
-
[[Category: Kemmink, J.]]
+
[[Category: Kemmink J]]
-
[[Category: Nilges, M.]]
+
[[Category: Nilges M]]
-
[[Category: Electron transport]]
+
-
[[Category: Endoplasmic reticulum]]
+
-
[[Category: Isomerase]]
+
-
[[Category: Redox-active center]]
+

Current revision

HUMAN PROTEIN DISULFIDE ISOMERASE, NMR, 40 STRUCTURES

PDB ID 1mek

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mek"
Personal tools