1k6i

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[[Image:1k6i.png|left|200px]]
 
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{{STRUCTURE_1k6i| PDB=1k6i | SCENE= }}
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==Crystal structure of Nmra, a negative transcriptional regulator (Trigonal form)==
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<StructureSection load='1k6i' size='340' side='right'caption='[[1k6i]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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===Crystal structure of Nmra, a negative transcriptional regulator (Trigonal form)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1k6i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_nidulans Aspergillus nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K6I FirstGlance]. <br>
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{{ABSTRACT_PUBMED_11726498}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6i OCA], [https://pdbe.org/1k6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k6i RCSB], [https://www.ebi.ac.uk/pdbsum/1k6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k6i ProSAT]</span></td></tr>
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[[1k6i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Emericella_nidulans Emericella nidulans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6I OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/NMRA_EMENI NMRA_EMENI] May be a redox sensor protein. Has much higher affinity for NAD(P) than for NAD(P)H. Has similar affinity for NAD and NADP. Negative transcriptional regulator involved in the post-transcriptional modulation of the GATA-type transcription factor areA, forming part of a system controlling nitrogen metabolite repression (By similarity). Interferes with the interaction between areA and target DNA. Overexpression leads to areA inhibition.<ref>PMID:17854403</ref> <ref>PMID:12764138</ref> <ref>PMID:15537757</ref> <ref>PMID:18602114</ref>
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<ref group="xtra">PMID:011726498</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Category: Emericella nidulans]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Cocklin, S.]]
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Check<jmol>
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[[Category: Dodds, A.]]
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<jmolCheckbox>
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[[Category: Hawkins, A R.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/1k6i_consurf.spt"</scriptWhenChecked>
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[[Category: Lamb, H K.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Leslie, K.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Nichols, C E.]]
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</jmolCheckbox>
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[[Category: Ren, J.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k6i ConSurf].
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[[Category: Stammers, D K.]]
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<div style="clear:both"></div>
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[[Category: Rossmann fold transcriptional regulation short chain dehydrogenase reductase]]
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== References ==
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[[Category: Transcription]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Aspergillus nidulans]]
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[[Category: Large Structures]]
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[[Category: Cocklin S]]
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[[Category: Dodds A]]
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[[Category: Hawkins AR]]
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[[Category: Lamb HK]]
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[[Category: Leslie K]]
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[[Category: Nichols CE]]
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[[Category: Ren J]]
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[[Category: Stammers DK]]

Current revision

Crystal structure of Nmra, a negative transcriptional regulator (Trigonal form)

PDB ID 1k6i

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