1njt

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[[Image:1njt.png|left|200px]]
 
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{{STRUCTURE_1njt| PDB=1njt | SCENE= }}
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==COMPLEX STRUCTURE OF HCMV PROTEASE AND A PEPTIDOMIMETIC INHIBITOR==
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<StructureSection load='1njt' size='340' side='right'caption='[[1njt]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1njt]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_betaherpesvirus_5 Human betaherpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NJT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NJT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CFT:TRIFLUOROMETHANE'>CFT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMH:N4,N4-DIMETHYL-ASPARAGINE'>DMH</scene>, <scene name='pdbligand=DMK:3,3-DIMETHYL+ASPARTIC+ACID'>DMK</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1njt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1njt OCA], [https://pdbe.org/1njt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1njt RCSB], [https://www.ebi.ac.uk/pdbsum/1njt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1njt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SCAF_HCMVA SCAF_HCMVA] Capsid scaffolding protein acts as a scaffold protein by binding major capsid protein UL86 in the cytoplasm, inducing the nuclear localization of both proteins. Multimerizes in the nucleus such as protein UL86 forms the icosahedral T=16 capsid. Autocatalytic cleavage releases the assembly protein, and subsequently abolishes interaction with major capsid protein UL86. Cleavages products are evicted from the capsid before or during DNA packaging (By similarity). Assemblin is a protease essential for virion assembly in the nucleus. Catalyzes the cleavage of the assembly protein after complete capsid formation. Assemblin and cleavages products are evicted from the capsid before or during DNA packaging (By similarity). Assembly protein plays a major role in capsid assembly. Acts as a scaffold protein by binding major capsid protein UL86. Multimerizes in the nucleus such as protein UL86 forms the icosahedral T=16 capsid. Cleaved by assemblin after capsid completion. The cleavages products are evicted from the capsid before or during DNA packaging (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nj/1njt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1njt ConSurf].
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<div style="clear:both"></div>
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===COMPLEX STRUCTURE OF HCMV PROTEASE AND A PEPTIDOMIMETIC INHIBITOR===
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==See Also==
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*[[Virus protease 3D structures|Virus protease 3D structures]]
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{{ABSTRACT_PUBMED_12549906}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Human betaherpesvirus 5]]
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[[1njt]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_5 Human herpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NJT OCA].
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[[Category: Large Structures]]
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[[Category: Bailey M]]
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==Reference==
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[[Category: Batra R]]
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<ref group="xtra">PMID:012549906</ref><references group="xtra"/>
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[[Category: Halmos T]]
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[[Category: Assemblin]]
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[[Category: Khayat R]]
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[[Category: Human herpesvirus 5]]
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[[Category: Qian C]]
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[[Category: Bailey, M.]]
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[[Category: Tong L]]
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[[Category: Batra, R.]]
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[[Category: Halmos, T.]]
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[[Category: Khayat, R.]]
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[[Category: Qian, C.]]
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[[Category: Tong, L.]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Induced-fit]]
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[[Category: Peptidomimetic inhibitor]]
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[[Category: Protease]]
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Current revision

COMPLEX STRUCTURE OF HCMV PROTEASE AND A PEPTIDOMIMETIC INHIBITOR

PDB ID 1njt

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