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1l8j

From Proteopedia

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[[Image:1l8j.png|left|200px]]
 
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{{STRUCTURE_1l8j| PDB=1l8j | SCENE= }}
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==Crystal Structure of the Endothelial Protein C Receptor and Bound Phospholipid Molecule==
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<StructureSection load='1l8j' size='340' side='right'caption='[[1l8j]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Crystal Structure of the Endothelial Protein C Receptor and Bound Phospholipid Molecule===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1l8j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L8J FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12034704}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l8j OCA], [https://pdbe.org/1l8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l8j RCSB], [https://www.ebi.ac.uk/pdbsum/1l8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l8j ProSAT]</span></td></tr>
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[[1l8j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L8J OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/EPCR_HUMAN EPCR_HUMAN] Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
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<ref group="xtra">PMID:012034704</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/1l8j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l8j ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dauter, Z.]]
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[[Category: Large Structures]]
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[[Category: Dongfeng, Q.]]
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[[Category: Dauter Z]]
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[[Category: Esmon, C T.]]
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[[Category: Dongfeng Q]]
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[[Category: Esmon, N L.]]
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[[Category: Esmon CT]]
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[[Category: Oganesyan, N.]]
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[[Category: Esmon NL]]
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[[Category: Oganesyan, V.]]
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[[Category: Oganesyan N]]
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[[Category: Terzyan, S.]]
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[[Category: Oganesyan V]]
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[[Category: Blood clotting]]
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[[Category: Terzyan S]]
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[[Category: Glycosilation]]
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[[Category: Hydrophobic groove]]
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[[Category: Mhc class1]]
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[[Category: Protein-lipid complex]]
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Current revision

Crystal Structure of the Endothelial Protein C Receptor and Bound Phospholipid Molecule

PDB ID 1l8j

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