1nbw

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[[Image:1nbw.png|left|200px]]
 
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{{STRUCTURE_1nbw| PDB=1nbw | SCENE= }}
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==Glycerol dehydratase reactivase==
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<StructureSection load='1nbw' size='340' side='right'caption='[[1nbw]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nbw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NBW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NBW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nbw OCA], [https://pdbe.org/1nbw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nbw RCSB], [https://www.ebi.ac.uk/pdbsum/1nbw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nbw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q59474_KLEPN Q59474_KLEPN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nb/1nbw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nbw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The function of glycerol dehydratase (GDH) reactivase is to remove damaged coenzyme B(12) from GDH that has suffered mechanism-based inactivation. The structure of GDH reactivase from Klebsiella pneumoniae was determined at 2.4 A resolution by the single isomorphous replacement with anomalous signal (SIR/AS) method. Each tetramer contains two elongated 63 kDa alpha subunits and two globular 14 kDa beta subunits. The alpha subunit contains structural features resembling both GroEL and Hsp70 groups of chaperones, and it appears chaperone like in its interactions with ATP. The fold of the beta subunit resembles that of the beta subunit of glycerol dehydratase, except that it lacks some coenzyme B(12) binding elements. A hypothesis for the reactivation mechanism of reactivase is proposed based on these structural features.
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===Glycerol dehydratase reactivase===
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Structure of glycerol dehydratase reactivase: a new type of molecular chaperone.,Liao DI, Reiss L, Turner I, Dotson G Structure. 2003 Jan;11(1):109-19. PMID:12517345<ref>PMID:12517345</ref>
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{{ABSTRACT_PUBMED_12517345}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1nbw" style="background-color:#fffaf0;"></div>
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[[1nbw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NBW OCA].
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== References ==
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<references/>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:012517345</ref><references group="xtra"/>
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</StructureSection>
[[Category: Klebsiella pneumoniae]]
[[Category: Klebsiella pneumoniae]]
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[[Category: Dotson, G.]]
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[[Category: Large Structures]]
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[[Category: Liao, D I.]]
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[[Category: Dotson G]]
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[[Category: Reiss, L.]]
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[[Category: Liao D-I]]
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[[Category: Turner, I.]]
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[[Category: Reiss L]]
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[[Category: Actin-like atpase domain]]
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[[Category: Turner Jr I]]
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[[Category: Beta/beta/alpha swiveling domain]]
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[[Category: Glycerol dehydratase]]
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[[Category: Hydrolase]]
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[[Category: Molecular chaperone]]
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[[Category: Reactivase]]
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Current revision

Glycerol dehydratase reactivase

PDB ID 1nbw

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